Wound Healing - Phases, Types of wound closure

Wound healing, types , pathology involved

1. WOUND HEALING

2. Phases of Healing Inflammatory (Reactive) Haemostasis Inflammation Proliferative (Regenerative/Reparative) Epithelial migration proliferation Maturation Maturational (Remodeling) Contraction scarring Remodeling

3. Phases of Wound Healing A. Inflammatory or reactive phase Events Increase vascular permeability Chemotaxis Secretion of cytokines Growth factor

4. Phases of Wound Healing B. Proliferative phase G ranulation tissue formation Events: Angiogenesis Fibroplasia Epithelization

5. Phases of Wound Healing C. Maturation phase Scar contraction with collagen cross-linking, shrinking and loss of edema Events: Scarring Contraction Remodeling of scar

6. Types of wound closure Primary closure Delayed primary closure Secondary closure

7. Primary closure First intention closure Wound edges opposed Normal healing Minimal scar Eg. emergency laceration repair, closure of the surgical wound

8. Primary closure

9. Secondary closure Wound left open Heals by granulation, contraction and reepithelialisation. Increased inflammation and proliferation Poor scar

10. Secondary closure

11. Delayed primary closure Tertiary intention Wound initially left open Edges opposed later when healing conditions are favourable

12. Delayed primary closure

13. Factors affecting Wound Healing