Young_Heart_Attacks_Clean_MasterCME.pptx

sudden deathn in young

1. Cardiac Arrest & Young Heart Attacks: India’s Emerging Crisis Neutral, Academic, Clean CME Deck ~100 Slides

2. Pathophysiology of Atherosclerosis

3. Chain of Survival

4. Algorithm: Evaluation of Young MI Step 1: History & family history Step 2: ECG, troponin, echo Step 3: Coronary angiography ± IVUS/OCT Step 4: Exclude MINOCA, vasospasm, myocarditis Step 5: Genetic/metabolic testing if indicated

5. Algorithm: Evaluation of Syncope in the Young Step 1: Detailed history (triggers, family SCD) Step 2: ECG (Brugada, LQTS, WPW) Step 3: Echo/CMR for structural heart disease Step 4: Holter/loop recorder, exercise test Step 5: Genetic testing if suspicion persists

6. Registry Data – NORIN-STEMI

7. SELECT Trial Results

8. Take-Home Messages Premature MI burden in India is high Pathophysiology: atherosclerosis + arrhythmic substrates CPR/AED essential to survival New interventions: BRS, PCSK9, GLP-1 Family screening & prevention crucial

9. References (1/3) NORIN-STEMI, ACS-QUIK, YOUTH registry INTERHEART South Asia ABSORB IV, MeRes100, DREAMS 3G

10. References (2/3) FOURIER, ODYSSEY, Inclisiran REDUCE-IT (Icosapent) SELECT (Semaglutide), SURPASS-CVOT

11. References (3/3) ICMR/AIIMS sudden death data Punjab HTN/obesity screening ILCOR 2022 CPR/AED consensus DISRUPT CAD (IVL)