Zentel (Albendazole Tablets)

Zentel (Albendazole Tablets) is used for the treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the pork tapeworm, Taenia solium.
Albendazole is indicated for the treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by the larval form of the dog tapeworm, Echinococcus granulosus. Zentel is effective against threadworm or pinworm, roundworm, whipworm, tapeworm and hookworm among others.

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Zentel (Albendazole Tablets)

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Zentel (Albendazole Tablets)
Zentel (Albendazole Tablets) is used for the treatment of
parenchymal neurocysticercosis due to active lesions caused
by larval forms of the pork tapeworm, Taenia solium.
Albendazole is used for the treatment of cystic hydatid
disease of the liver, lung, and peritoneum, caused by the
larval form of the dog tapeworm, Echinococcus granulosus.
Zentel is effective against threadworm or pinworm,
roundworm, whipworm, tapeworm and hookworm among
others.

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Zentel (Albendazole Tablets)
Active Ingredient
The active ingredient contained in Zentel
tablets is Albendazole.
Each Zentel tablet contains 400 mg of
Albendazole.

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Zentel (Albendazole Tablets)
Chemical Structure
The structure of Albendazole is given below:

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Zentel (Albendazole Tablets)
Zentel Tablets are manufactured by GlaxoSmithKline
Pharmaceuticals Limited, India in the strength of 400 mg.
( Website: https://india-pharma.gsk.com/ )

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Zentel (Albendazole Tablets)
Albendazole Tablets – Brand Names
Albendazole tablets are available under
various drug trade names that include
Zentel, Bendex Albenza ,Aban and Aben.

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Zentel (Albendazole Tablets)
Uses of Zentel Tablets
Zentel (Albendazole Tablets) is used to treat
neurocysticercosis, an infection of the nervous system caused
by pork tapeworms. This medicine is also used to treat cystic
hydatid disease of the liver, lung, and peritoneum, an infection
caused by dog tapeworms.
Albendazole is used to treat infections caused by worms. It
works by keeping the worm from absorbing sugar (glucose), so
that the worm loses energy and dies.
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Zentel (Albendazole Tablets)
Zentel Tablets Dosage

The dosage of Zentel tablets (Albendazole Tablets) is given
below:
The usual dose is 400 mg (one Zentel 400 tablet) as a single dose
in both adults and children over two years of age.
In heavy mixed infestation involving Strongyloides or Taeniasis, a
single daily dose may be inadequate and the dose may be given for
three consecutive days.
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Zentel (Albendazole Tablets)
Zentel Tablets Dosage

The dosage of Zentel tablets (Albendazole Tablets) is given
below:
Giardiasis (dose in children over 2 years of age): A single 400 mg
(one Zentel 400 tablet) daily dose for five days. Some people,
particularly young children, may experience difficulties swallowing
the tablets whole and should be encouraged to chew the tablets
with a little water; alternatively tablets may be crushed and mixed
with food.
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Zentel (Albendazole Tablets)
Contraindications
Zentel tablets are contraindicated in patients with a
hypersensitivity to Albendazole or any other component of this
medication.
Zentel (Albendazole Tablets) are contraindicated during
pregnancy or in women believed to be pregnant.
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Zentel (Albendazole Tablets)
Storage Instructions

Zentel (Albendazole Tablets) have to be
stored at controlled room temperature i.e.
from 20°C to 25°C (68°F to 77°F) with
excursions permitted between 15° to 30°C
(59° to 86°F).
Keep this as well as all other medicines away
from children and pets.
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Zentel (Albendazole Tablets)
Warnings

Patients should be advised to inform their doctor or pharmacist if they are
allergic to Zentel; or to other Benzimidazole anthelmintic drugs (such as
Mebendazole); or if they have any other allergies. This medicine may
contain inactive ingredients, which may cause allergic reactions or other
adverse effects. Also inform your doctor or pharmacist your medical
history, especially of: liver disease, biliary tract problems (such as
blockage), blood/bone marrow disorders.
This medication can cause liver problems. Since drinking alcohol
increases the risk of liver problems, limit alcoholic beverages while using
this medication. Patients should be advised to inform their doctor or
dentist about all the medicines they take including prescription drugs,
nonprescription drugs, and herbal products in case of surgery.

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Zentel (Albendazole Tablets)
Warnings

Leucopenia may occur when Zentel 400 is used for periods longer than
recommended. In order to avoid administering Zentel 400 during early
pregnancy, women of childbearing age should initiate treatment during the first
week of menstruation or after a negative pregnancy test.
Sub-clinical neurocystercosis may manifest after a single dose of Zentel 400.
Treatment with Albendazole may uncover pre-existing neurocysticercosis,
particularly in areas with high taenosis infection. Patients may experience
neurological symptoms e.g. seizures, increased intracranial pressure and focal
signs as a result of an inflammatory reaction caused by death of the parasite
within the brain. Symptoms may occur soon after treatment, appropriate steroid
and anticonvulsant therapy should be started immediately.
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase
deficiency or glucose-galactose malabsorption should not take this medicine.

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Zentel (Albendazole Tablets)
Warnings

Effects on ability to drive and use machines: Since dizziness
has been reported following treatment with Zentel
(Albendazole Tablets), caution is recommended in patients
performing skilled tasks.

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Zentel (Albendazole Tablets)
Side Effects
Common Side effects of Zentel include Nausea, vomiting,
abdominal pain, headache, or temporary hair loss. In case any of
these effects last or get worse, tell your doctor or pharmacist
promptly.
Inform your doctor right away if you have any serious side effects,
including: severe headache that doesn't go away, vision changes,
yellowing eyes/skin, severe stomach/abdominal pain, dark urine,
unusual tiredness, easy bruising/bleeding, signs of infection (such
as sore throat that doesn't go away, fever, chills), signs of kidney
problems (such as change in the amount of urine), confusion, very
stiff neck.
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Zentel (Albendazole Tablets)
Side Effects
Get medical help immediately in case you have any very
serious rare side effects, including: seizures.
A very serious allergic reaction to this medicine is rare.
However, get medical help immediately in case you notice
any symptoms of a serious allergic reaction, including: rash,
itching/swelling (especially of the face/tongue/throat),
severe dizziness, trouble breathing.
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Zentel (Albendazole Tablets)
Overdose
Significant toxicity and mortality were observed in animal studies and
symptoms were observed in a dose-response relationship which included
diarrhoea, vomiting, tachycardia and respiratory distress.
One case of overdosage has been reported with Albendazole in a patient
who took at least 16 grams over 12 hours. No untoward effects were
reported.
In case of overdosage, symptomatic therapy (e.g. gastric lavage and
activated charcoal) and general supportive measures are recommended.
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Zentel (Albendazole Tablets)
Zentel Tablets During Pregnancy
Albendazole is classified by the US FDA as Pregnancy
Category C . Use of Zentel is contraindicated during
pregnancy and for 1 month prior to conception. A negative
pregnancy test must be obtained before starting therapy
or therapy should be started during the first week of
menstruation.
There are no adequate and well-controlled studies of
Albendazole administration in pregnant women.
Albendazole should be used during pregnancy only if the
potential benefit justifies the potential risk to the foetus.
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Zentel (Albendazole Tablets)
For more details on
Zentel Tablets click here
Zentel (Albendazole Tablets) by GlaxoSmithKline Pharmaceuticals
Limited, India.
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