Adrenergic_Drugs_HalfLife_PKBr new fuĺ.docx

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1. Half Life of Adrenergic Agonists and Blockers
Course Name: Biopharmaceutics and Pharmacokinetics
Course Code: PH4213
Instructor Name: Sir Sadaqat Hussain Awan
Student Name: Arsalna Humayun
Registration No. BPH223083
Section: 01
Assignment No. 01

2. Capital University of Science and Technology, Islamabad
Adrenergic Agonists and Blockers (Half-life + Generic & Brand Names)
Category Drug Name (Generic +
Common Brands in
Pakistan)
Class Approx
Half Life
Uses
Very Short
Half Life
Epinephrine
(Adrenaline Inj)
Alpha &
Beta agonist
2–3 minAnaphylaxis,
cardiac arrest
Very Short
Half Life
Norepinephrine
(Levophed Inj)
Alpha &
Beta1
agonist
2.5 minSeptic shock,
hypotension
Very Short
Half Life
Dopamine (Dopamine
Inj)
D1, Beta1,
Alpha
agonist
2 min Shock, low
cardiac output
Very Short
Half Life
Dobutamine (Dobutrex
Inj)
Beta1
agonist
2 min Acute HF,
cardiogenic shock

3. Very Short
Half Life
Esmolol (Brevibloc Inj)Beta1
blocker
9 min Acute tachycardia
Short Half
Life
Phenylephrine
(Neosynephrine / Neo
Spray)
Alpha1
agonist
2–3 hr Decongestant,
hypotension
Short Half
Life
Isoproterenol (Isuprel
Inj)
Non
selective
Beta agonist
2–5 hr Bronchospasm,
AV block
Short Half
Life
Salbutamol (Ventolin,
Asthalin)
Beta2
agonist
3–6 hr Asthma relief
(SABA)
Short Half
Life
Propranolol (Inderal)Non
selective
beta blocker
3–6 hr HTN, anxiety,
arrhythmia
Short Half
Life
Metoprolol (Betaloc,
Lopressor)
Beta1
blocker
3–7 hr HTN, angina, post
MI
Intermediate
Half Life
Clonidine (Catapres /
Dixarit)
Alpha2
agonist
10–20 hrResistant HTN,
withdrawal
Intermediate
Half Life
Atenolol (Tenormin /
Tenolol)
Beta1
blocker
6–7 hr HTN safer in
asthma
Intermediate
Half Life
Labetalol (Trandate,
Normabel)
Alpha1 +
Beta blocker
5–8 hr Pregnancy HTN
Intermediate
Half Life
Carvedilol (Dilatrend,
Coreg)
Alpha1 +
Beta blocker
7–10 hrCHF, HTN
Long Half
Life
Salmeterol (Serevent,
Seretide Combo)
Beta2
agonist
(LABA)
12 hr COPD, asthma
maintenance
Long Half
Life
Formoterol (Oxis,
Foradil, Symbicort
Combo)
Beta2
agonist
(LABA)
12 hr Maintenance
inhaler
Long Half
Life
Nadolol (Corgard) Non
selective
beta blocker
20–24 hrLong term HTN
control
Long Half
Life
Nebivolol (Nebilet)Beta1
blocker +
NO release
10–30 hrHTN with
vasodilation
benefit
Long Half
Life
Terazosin (Hytrin)Alpha1
blocker
12 hr BPH, HTN
Long Half
Life
Prazosin (Minipress /
Vasofix)
Alpha1
blocker
2–3 hr BPH symptom
relief (short t½)