Amoxicillin product-information

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1. Amoxicillin Product Information

2. Composition Each 100gm contains: Amoxycillin trihydrate : 46gm equivalent to amoxicillin base 40gm

3. Amoxicillin Amoxycillin Semi synthetic antibiotic, an analog of ampicillin. Broad spectrum of bactericidal activity. Amoxycillin forms There are various hydrated forms of amoxicillin, including monohydrate, dihydrate , and trihydrate , among which, trihydrate is the most stable form.

4. Pharmacokinetics / Absorption Amoxicillin bioavailability reaches 95% Amoxicillin is a weak acid; In acidic media, it is better absorbed as a non ionized form (lipid soluble) for better penetration of the intestinal membrane. In Alkaline media, it becomes ionized (water soluble) which means it will be eliminated non absorbable.

5. Pharmacokinetics / Distribution amoxicillin was administered to eight chickens at a dose of 20 mg/kg of body weight orally; Cmax 1.382 µg/ml Tmax 2 hr T1/2 2.433 hr AUC 4.506 µg/h/l

6. Pharmacokinetics µg/ml

7. Amoxicillin MIC

8. Bacterial Cell Wall Structure Peptidoglycan constitute almost 95% of the cell wall in some Gram positive bacteria and as little as 5-10% of the cell wall in Gram negative bacteria.

9. Mechanism of action Amoxicillin acts by inhibiting the synthesis of bacterial cell wall. It inhibits cross linkage between the linear peptidoglycan polymer chains that make up a major component of the cell walls of both Gram positive and Gram negative bacteria.

10. Spectrum of activity Bactericidal antibiotic against wide range of gram+ve and gram- ve bacteria: Clostridium spp. E. coli Salmonella spp. Penicillin sensitive staphylococci

11. Indications Necrotic and ulcerative enteritis, caused by Clostridium sp . Gangrenous dermatitis.

12. Dosage 20mg/kg bird live weight/day for 3 - 5 consecutive days. 1 bottle for 10 tons of live body weight.

13. Administration Turn off drinkers for 2 hours. Calculate number of amoxicillin WSP bottles to administer. Dissolve the contents of each bottle in a small amount of water . Immediately add this solution to a volume of water representing bird’s expected water consumption over the next 2-3 hours. Once all the medicated water is consumed, the bird’s normal fresh water supply must be resumed. Repeat this procedure daily for 3-5 days .

14. Precautions No withdrawal period

15. Package Bottle of 500gm