AMRUTADI GUGGULU

Dr. Ajith The famous Integrative dermatology practitioner. And all the ppt which i have updated is prepared by myself and if you find out the same in anywhere else, inform us and its 100% copied from my profile.

1. FORMULATION SEMINAR AMRUTADI GUGGULU Dr.Ajith Kumar Final Year M.D scholar Dept of Rasashastra and Bhaishajya Kalpana KLE SHRI B.M.K.A.M AND HOSPITAL BELAGAVI 1 FORMULATION SEMINAR- AMRUTADI GUGGULU 20-07-2023

2. CONTENT Introduction Objectives Reference Ingredients Indications Contraindications Pharmaceutical aspects Critical analysis of the ingredients FORMULATION SEMINAR- AMRUTADI GUGGULU 2 Manufacturing companies Researches Discussion Case study Own research views Summary Conclusion 20-07-2023

3. INTRODUCTION Amruta refers to Guduchi which is main ingredient in this formulation. Amrutadi Guggulu is a polyherbal classical Ayurvedic medicine. It is used for the treatment of various diseases like piles, gout, skin diseases, rheumatoid arthritis, fistula, decreased digestive power. It is also useful in the management of obesity. This Ayurvedic preparation balances all the three doshas, predominantly vata and Kapha . FORMULATION SEMINAR- AMRUTADI GUGGULU 3 20-07-2023

4. OBJECTIVES To study the method of preparation of Amrutadi guggulu . To analyse the rationality behind its ingredients. To discuss some of the research works related to this formulation. Application of Amrutadi guggulu in clinical practice. FORMULATION SEMINAR- AMRUTADI GUGGULU 4 20-07-2023

5. REFERENCE FORMULATION SEMINAR- AMRUTADI GUGGULU 5 20-07-2023 Bhava Prakash Madhyama khanda Vatarakta chikitsa Bhaishajya Ratnavali 27/84-90 Amrutadi guggulu 1 Amrutadi guggulu 2

6. INGREDIENTS FORMULATION SEMINAR- AMRUTADI GUGGULU 6 Kashaya Dravya  (materials for preparing decoction) Guduchi /Amruta ( Tinospora cordifolia ) – 1 prastha (768gms) Guggulu ( Commiphora mukul ) - 1/2 prastha (384gms) Triphala – 1/2 prastha each Haritaki (Terminalia chebula ) Bibhitaki (Terminalia bellerica ) Amalaki ( Emblica Officinalis ) 20-07-2023

7. INGREDIENTS Prakshepaka Dravyas  (powdered drugs) Danti ( Baliospermum montanum ) – 1/2 pala (24 gms ) Vyosha / Trikatu – 1/2 pala each (24 gms ) Shunti   (Zingiber officinale ) Maricha (Piper nigrum) Pippali (Piper longum) Vidanga ( Embelia ribes ) – 1/2 pala (24 gms ) Twak (Cinnamomum zeylanicum) – 1/2 pala (24 gms ) Trivrit ( Operculina turphethum ) – 1 Karsha ( 12 gms ) 6 . Water – 1 Drona 12 L 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 7

8. INDICATION FORMULATION SEMINAR- AMRUTADI GUGGULU 8 Vatarakta  – A variety of joint and skin disorders/?Gout Kushta  – Skin diseases Gudaja roga   – Piles/Haemorrhoids, Fissures Agnisaada  – Impairment of digestive fire Dushta Vrana   – Non-healing ulcers Prameha  – Diabetes Amavata  – A type of joint pain/?Rheumatoid arthritis Bhaghandhara  – Fistula in ano Nadi roga   – Vataja diseases Adhya vata   – Kapha vataja diseases Shwayathu  – Swelling Sarva roga hara  – Cures all the diseases 20-07-2023

9. CONTRA-INDICATION This medicine should be avoided by the people having IBS – diarrhea and sensitive stomach. Avoid this medicine during pregnancy and lactation. It can worsen gastritis in few cases. Better avoid in children below 6 years of age or prescribed only in lower doses. FORMULATION SEMINAR- AMRUTADI GUGGULU 9 20-07-2023

10. PHARMACEUTICAL ASPECT- PURVA KARMA FORMULATION SEMINAR- AMRUTADI GUGGULU 10 Collection of ingredients: 20-07-2023 Guduchi Guggulu Haritaki

11. 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 11 Vibhitaki Amalaki Danti

12. 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 12 Vidanga Shunti Maricha

13. 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 13 Pippali Twak Trivrith

14. Pharmaceutical aspects - Pradhanakarma Guduchi and guggulu are taken along with triphala in a clean vessel then added 1drona of water reduces to 1/4 th Filter the decoction to get rid of impurities After filtering the obtained Kashaya is again heated till it becomes thick Added the 24 grams of each of the rest of the ingredients mentioned above one by one. ( Trivrath 1 karsha ) A semi-solid mass is formed. Collected semisolid mixture are rolled into pills. FORMULATION SEMINAR- AMRUTADI GUGGULU 14 20-07-2023

15. Pharmaceutical aspects - Pashchatkarma Prepared vatis - to be dried under shade Weighed and stored in airtight container FORMULATION SEMINAR- AMRUTADI GUGGULU 15 20-07-2023

16. Pharmaceutical aspects - Large scale production Drugs are powdered using pulveriser. The powdered drugs are added to the Mass mixer. Shuddha guggulu are added to the mass mixer After proper mixing, the content is taken for tablet punching. 16

17. Critical analysis of the ingredients DRAVYA RASA GUNA VIRYA VIPAKA KARMA 1. Guduchi Tikta Kashaya Guru Snigda Ushna Madhura Tridoshaghna 2. Guggulu Katu Tikta Laghu Rooksha Vishada Ushna Katu Tridoshaghna 3. Haritaki Kashaya pradana pancharasa Laghu Rooksha Ushna Madhura Tridoshaghna ( Vatashamaka ) 4. Vibhitaki Kashaya Laghu Rooksha Ushna Madhura Tridoshaghna ( Kapha shamaka ) 5. Amalaki Amla pradana pancharasa Guru Rooksha Sheeta Sheeta Madhura Tridoshaghna FORMULATION SEMINAR- AMRUTADI GUGGULU 17 20-07-2023

18. DRAVYA RASA GUNA VIRYA VIPAKA KARMA 1. Danti Katu Guru Teekshna Ushna Katu Pitta kapha hara 2. Shunti Katu Guru Ruksha Teekshna Ushna Madhura Vatakapha hara 3. Maricha Katu Laghu Teekshna Sookshma Ushna Katu Vatakapha hara 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 18

19. 4. Pippali Katu Laghu Tikshna Ushna Madhura Kaphavata hara 5. Vidanga Katu Kashaya Laghu Rooksha Tikshna Ushna Katu Kaphavatashamaka 6. Twak Katu Madhura Tikta Laghu Rooksha Tikshna Ushna Katu Vatakapha hara 7. Trivrit Tikta Katu Laghu Rooksha Teekshna Ushna Katu Pittakapha hara 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 19

20. Critical analysis of the ingredients DRUG AYURVEDIC VIEW MODERN VIEW 1. GUDUCHI Vayasthapana Trishnanigraha Triptighna Dahaprashamana Stanyashodhana Jvaraghna It is used as antipyretic, CNS depressant, hypoglycemic , antiarthritic, anti-inflammatory, anti-allergic, hepatoprotective, antioxidant, antistress, hypotensive, diuretic, antimicrobial activity. 2. GUGGULU Ushna , acts as deepana and pachana Medohara and thus helps treating obesity Helps in getting rid of cholesterol by converting it into bile, is an effective remedy for removing the unwanted fats and balancing the cholesterol levels 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 20

21. Critical analysis of the ingredients DRUG AYURVEDIC VIEW MODERN VIEW 3. HARITAKI Anulomana Rasayana Srotahshodhana Contains tannins, that are antioxidant, atherosclerosis, cardiovascular diseases, neurodegenerative diseases, and certain types of cancers 4. VIBHITAKI Anulomana and thus helps clearing the koshtha and thereby removing ama Laxative, valuable remedy for digestive disorders and effective anthelmintic Contains chebulagic acid which is a benzopyran tannin and an antioxidant that has many potential uses in medicine; has been found to be hepatoprotective 5. AMALAKI Rasayana Vayassthapaka , helps in the absorption of iron due to the presence of ascorbic acid Improves liver function. antibacterial, carminative, hypoglycaemic, stomachic, hypotensive, antioxidative, anti hepatotoxic and immune modulator properties 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 21

22. Critical analysis of the ingredients DRUG AYURVEDIC VIEW MODERN VIEW 6. DANTI Deepana, Pachana , Kanduhara , Krimihara Kushtahara Dushtavrana shodhana Arshoghna Shoolahara It acts as blood purifier It reduces edema and pain Antipyretic, Laxative, Anticancer, Antioxidant, Antimicrobial, Hepatoprotective. Its very effective in abdominal pain, bloating and abdominal tumors. 7. SHUNTI Deepana Pachana Truptighna Shoolaprashamana Arshoghna Trishna nigrahana Ginger is effective in arthritis, rheumatoid arthritis, dizziness, menstrual pain, anemia, elephantiasis, motion sickness and weight loss. Hepatoprotective, Cardioprotective Antiinflamatory , Appetizer, Aphrodisiac Useful in respiratory disorders like asthma 8. MARICHA Deepana Pachana Shoolaprashamana Krimighna Piper nigrum are rich resource of medicinal properties like it is carminative, anti- inflammatory, anti-cancer, anti-oxidant, anti-microbial, antidiarrheal, anthelmintic, antispasmodic, analgesic, and anti-stress, anti-diabetic and antipyretic etc. in nature 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 22

23. DRUG AYURVEDIC VIEW MODERN VIEW 9. PIPPALI Deepana, Pachana , Kantya Kushtahara , sheetaprashamana , shoolaprashamana Kasahara, shwasahara Gulmahara Vrushya etc. Detoxifier, worm infestations, chronic dysentery, Splenomegally Helps in asthma, cough, cold, aphrodisiac. Cardiac disorders, Anaemia, intestinal worm infestation. 10. VIDANGA Agnimandhya Krimighna Kushtaghna Aruchihara Pramehahara Shulahara Adhmanahara Antimicrobial Helps in skin disease Carminative and digestants Loss of appetite, abdominal distension, constipation etc 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 23 Critical analysis of the ingredients

24. Critical analysis of the ingredients DRUG AYURVEDIC VIEW MODERN VIEW 11. TWAK Krimihara Amahara Kandu Vataja arsha Amavatahara Vishapaha Basthishodhana etc. Antibacterial and antifungal Used in rheumatoid arthritis Expectorant and antitubercular activity Helps in neurodegenerative disease like Alzheimer’s, Parkinson's disease Cardioprotective etc. Helps to reduce glucose level 12. TRIVRIT Virechaka Krimihara Jvaraghna Panduhara Shophahara Pleeha Hridroga Purgative Helps in abdominal distension, abdominal cramp, constipation, jaundice, haemorrhoids, Rheumatic joint disease etc Ued in generalised oedema and fever 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 24

25. Dosage Traditional dose is - 1 Karsha - up to 12 grams per day, as per digestive strength of the patient. In practice, it is administered in a dose of 1-2 tablets, 2-3 times a day, usually after food. 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 25

26. Anupana Guduchi kvatha or according to roganusara . Based on disease, many liquids are administered along with this tablet. Example: Abhayarishta , in case of hemorrhoids and fistula. Mahamanjishtadi Kashaya or Nimbadi Kashaya or Aragvada kashaya - in skin diseases, non healing wounds, vasculitis etc. Asanadi kashaya in case of obesity, low digestive strength. 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 26

27. MANUFACTURING COMPANIES FORMULATION SEMINAR- AMRUTADI GUGGULU 27 20-07-2023 Dhootapapeshwara Planet Ayurveda Basic Ayurveda

28. MANUFACTURING COMPANIES 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 28 Saived Pharma Punarvasu Pharma Rasashala Pharma

29. MANUFACTURING COMPANIES 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 29 Deep Ayurveda Pharma Uja Pharma Ashtanga Herbals

30. Cost analysis 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 30 Company Cost (Rs.) Packing Cost per tab (Rs.) Dhootpapeswar 140.00 60 tabs 2.333 Planet Ayurveda 415.00 120 tabs 3.458 Basic Ayurveda 67.00 40 tabs 1.675 Saived Pharma 115.00 60 tabs 1.916 Deep Ayurveda Pharma 160.00 60 tabs 2.666 Uja Pharma 147.00 60 tabs 2.45

31. RESEARCH ARTICLE FORMULATION SEMINAR- AMRUTADI GUGGULU 31 20-07-2023

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33. CONCLUSION The study shows that as described in ancient Ayurveda literature Vata-rakta is a disease this characterised by pain, burning, swelling, and itching at particular site of the joints especially in meta- tarso -phalangeal joint and knee joints which is also described in case of Gout by contemporary literature. Vata-rakta is purely Shakha-gata disease which is caused by vitiation of Vata with disordered property of Rakta hence it is called Vata and Rakta- vikara . Amrita Guggulu has significant effect on the symptoms of Vata-rakta as described in our texts and this study has proved the same. Amrita Guggulu is also very significant effect on the level of serum uric acid, which is a prominent marker of diagnosis and prognosis of Vatarakta with special reference to disease Gout. Although the formulations, Amrita Guggulu -I and Amrita Guggulu -II have minor differences in its ingredients yet played almost same role on disease Vata-rakta which got proved by clinical study. (10 subjective parameters) 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 33

34. FORMULATION SEMINAR- AMRUTADI GUGGULU 34 20-07-2023

35. CONCLUSION According to modern science excessive adipose deposition in the body is the prime reason for manifestation of disease and natural products can play a safe and effective role with obesity specially those containing fibers, polyphenols, sterols, and alkaloids. Amritadya Guggulu having Antiobesity , Immunomodulatory, Prokinetic, Hypolipidemic, Thermogenesis property possesses a core mechanism for the treatment of Sthoulya (Obesity). In Ayurveda, as equilibrium of Doshas is the main aim of treatment of disease, properties like Srotoshodhana , Ama Pachana Shodhana , Vata Shamana , Lekhana , Shoshara , Kleda as well as Meda Vilayna will be beneficial in Sthoulya . So, Amritadya Guggulu is considered to be a safe Ayurvedic drug for the treatment of Sthoulya and its associated disorders mentioned in Ayurveda Classics. FORMULATION SEMINAR- AMRUTADI GUGGULU 35 20-07-2023

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37. CONCLUSION From the observation of the study it is found that both the drugs are effective in reducing the sign and symptoms of Vatarakta but while coming to the comparison Amrutadi Guggulu is more effective than the Kaishora Guggulu in the present study. 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 37

38. DISCUSSION Proper preparation of Amrutadi guggulu is very important rather than using it clinically. Authentic drug should be used in the preparation to get the required therapeutic property. Most of the drugs are Katu rasa, Laghu, Ruksha guna and Ushna veerya so that sometime it may lead to severe gastritis to the patient. Amrutadi guggulu having maximum action is on Skin and Liver. It is having uricosuric property which helps to reduces uric acid and prevents uric acid accumulation on the joints. It reduces joint pain and swelling in rheumatoid arthritis. It is having antimicrobial action which helps to reduces many skin infections. It improves digestion by reducing Ama. FORMULATION SEMINAR- AMRUTADI GUGGULU 38 20-07-2023

39. CASE 1 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 39 H /O- Kandu , Srava , Shotha Subjective parameters Agni Koshta Prakrathi Dosha Nidana Lakshana Diagnosis: Vicharchika ( Kapha vataja ) (Wheeping eczema) Plan for Rx - Based on Trisutra of ayurveda Rx given Amrutadi guggulu along with Aragvada Kashaya. Followed by other medication and external application.

40. CASE 2 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 40 Same as Case 1

41. Case 3 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 41 H/O- Kandu , Rukshata Subjective parameters Agni Koshta Prakrathi Dosha Nidana Lakshana Diagnosis: Dadru ( Kapha vataja ) (Tinea corporis infection) Plan for Rx - Based on Trisutra of ayurveda Rx given Amrutadi guggulu along with Nimbadi Kashaya. Followed by other medication and external application.

42. Case 4 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 42 H/O- Kandu , Ruksha , Powder discharge (Flakes) Subjective parameters Agni Koshta Prakrathi Dosha Nidana Lakshana Diagnosis: Kitibha kushta - Tridoshaja (Psoriasis) Plan for Rx - Based on Trisutra of ayurveda Rx given Amrutadi guggulu along with Patolakaturohinyadi kashaya . Followed by other medication and external application.

43. OWN RESEARCH VIEWS Clinical study of Amrutadi guggulu with different Anupana in different conditions like skin disease, vataraktha etc. Clinical studies can be carried out on the other indications of Amrutadi guggulu such as Sthoulya , post operative pain conditions etc. Modification into different dosage forms . FORMULATION SEMINAR- AMRUTADI GUGGULU 43 20-07-2023

44. SUMMARY Introduction Objectives Reference Ingredients Indications Contraindications Pharmaceutical aspects Critical analysis of the ingredients FORMULATION SEMINAR- AMRUTADI GUGGULU 44 Manufacturing companies Researches Discussion Case study Own research views Summary Conclusion 20-07-2023

45. CONCLUSION Amrutadi guggulu helps in maintenance of healthy digestive system. It is used for the treatment of various diseases like piles, gout, skin diseases, rheumatoid arthritis, fistula. It promotes agni , digestive fire, does shodhana of srotas and thus helps the nutrients to reach the tissues, balances fats in the body and removes toxins by improving the digestive system. Improves overall health. Further study and knowledge from experienced physicians are required to explore the full potential of the Amrutadi guggulu . FORMULATION SEMINAR- AMRUTADI GUGGULU 45 20-07-2023

46. 20-07-2023 FORMULATION SEMINAR- AMRUTADI GUGGULU 46 “Practice dermatology for a better future career” THANK YOU FOR THE PATIENCE Skills_of_dermatology drajithgkumar_derma Doctor_ofskin