Challenges in formulation of Herbal Cosmetics

Challenges in formulation of Herbal Cosmetics

1. Challenges In Formulation of Herbal Cosmetics Submitted by: ARNAB DEY M.Pharm ; 1 st Year Pharmaceutics PES College of Pharmacy 1 March 2019 1

2. Contents : Cosmetics : Introduction Herbal cosmetics Herbal extracts for cosmetics Formulation Challenges Constrains of Herbal formulation References 1 March 2019 2

3. Cosmetics Cosmetics  are substances or products used to enhance or alter the appearance of the face or fragrance and texture of the body. Many cosmetics are designed for use of applying to the face, hair, and body. They are generally mixtures of chemical compounds; some being derived from natural sources (such as coconut oil), and some being synthetics or artificial. Common make-up items include: lipstick ,  eye shadow, foundation. Whereas other common cosmetics can include skin cleansers and body lotions, shampoo and conditioner, hairstyling products (gel, hair spray, etc.), perfume and  cologne. Definition: “ Any article intended to be rubbed, poured, sprinkled, sprayed, introduced to or applied to any part of human body for cleansing, beautifying, promoting attractiveness or altering the appearances of human body are cosmetics.” (Drug and Cosmetic Act, 1940) 1 March 2019 3

4. Herbal Cosmetics Herbal cosmetics, referred as products,are formulated using various permissible cosmetics ingredients to form the base in which one or more herbal ingredients are used to provide defined cosmetic benefits only, shall be called as Herbal Cosmetics. These formulation include comminuted or powered herbal substances, tinctures , extracts essential natural oils, expressed juices and processed exudates which are obtained by subjecting herbal substances to treatments such as extraction, distillation, expression, fractionation, purification or fermentation processes . 1 March 2019 4

5. Herbal extracts for cosmetics Herbal extracts as the name suggests, is the extract of herbs . Herbal extracts are an ancient methodology as its references have been discovered in holy Vedas and in unani scriptures . Herbals extracts are processed for curing several remedies and serve other health prospective . There exist a gigantic variety of herbal extracts, to name a few Ocimum sanctum ( Tulsi ), Asparagus Racemosus ( Shatawari ), Azadirachta Indica ( Neem ), Asphalt ( Shilajit ), Camellia Sinensis (Green tea) etc . Herbal extracts in liquid and other forms have proved to be panacea in the diseases like cardiac problems, digestive disorders and in mental fatigues. In some cases, herbal extracts accuracy was detected more than allopathic medicines which are usually comprised of complex chemicals. 1 March 2019 5

6. Contd … Herbal extracts have very less chances of side effects than any other medicines. Herbal extracts are cultivated all over the world and is prime name in horticulture sector at present . In the present, masses are drifting towards nature and several cosmetics, fashionable items and others are prepared from it. Cosmetics made up of herbal extracts for antimarks , fairness, cleansing and hair-care are very popular for their reliability. 1 March 2019 6

7. Challenges A key challenge is to objectively assess conflicting toxicological, epidemiological and other data and the verification of herbal materials used . Unlike conventional cosmetics, there is extremely insufficient documentation of herbal cosmetics. Most herbal cosmetics depend on traditional methods or Ayurvedic formulations in their manufacturing. Some of these are passed down through generations, while some are documented. Even when documented , few of these can compare to the extensive clinical, pharmacological , and toxicological documentation available for conventional beauty products. 1 March 2019 7

8. Contd … Herbal ingredients needs special care and precautions during the complete phase of extraction process. Proper drying conditions should be adhered. Improper drying may lead to unintentional adulteration. e.g. if digitalis leaves are dried above 65ºC decomposition of glycosides by enzymatic hydrolysis. No specific standardization : there is no single standard that will apply to herbal cosmetic formulations, so no any good way to decide whether ingredient can be used or not, to which extent and what standards. -- Since the processing of one batch often differed fron another, a single company’s own product line may not have a standard output. -- This makes compliance with certain rules difficult, especially in some developed markets. 1 March 2019 8

9. Contd … Few ingredients: Only few ingredients of natural origin can be used as preparation is nature based cosmetics. No synthetic surfactant, few preservatives can only be used. So there is uncertainty in best product preparation. The problem of formulating with less ingredients may lead to the formation of product that may not work as well with synthetic chemical based competition . Consumers shall do some compromises for the fact that they are using natural based products but do not want to give up functionality for the sake of naturalness or sustainability as this is the beauty business. 1 March 2019 9

10. Contd … Stability problem : One of the main problem faced in formulating herbal cosmetics preparation is the stability of herbal component both prior and after formulation as they are to be degrade easily by many physiochemical process. -- Deterioration happens especially during storage, leading to the loss of the active ingredients, production of metabolites with no activity and in extreme cases the production of toxic metabolites. -- Physical factors such as air (oxygen), humidity, light, and temperature can bring about deterioration directly or indirectly. Safety and efficacy assessment has to be developed on each batch of manufacturing cycle thus the task become more tedious and time consuming. 1 March 2019 10

11. Contd … From the manufacturer points of view, raw materials in bulk quantity and quality is hard to obtain which leads breakage in continuous production cycle of herbal cosmetics . -- Raw materials obtained from different place with varying climate cannot be treated as same as there arises difference in herbal potency. -- No specific criteria is given which may lead to irregularity in production cycle. Poor quality of raw materials: Herbal cosmetics require the careful cultivation of plants and herbs in their natural environment . -- The raw material for herbal cosmetics company cannot be mass produced in a factory. Neither can one produce these in a matter of minutes in a laboratory. 1 March 2019 11

12. Constrains of Herbal formulation Constrains associated with handling of medicinal plants : Indiscriminate harvesting and poor post-harvest treatment practices . Lack of research on development of high-yielding varieties, domestication etc. Poor agriculture and propagation methods . Inefficient processing techniques leading to low yield and poor quality products. Poor quality and control procedures. 1 March 2019 12

13. Contd … Lack of cGMP for preparation. Lack of R&D on product and process development . Difficulties in marketing . Lack of trained personnel and equipment . Lack of facilities to fabricate equipment locally . Lack of access to latest technological and market information 1 March 2019 13

14. B. Constrains associated with the dealing of Herbal Medicines: Both the raw herb and the extract contain complicated mixtures of organic chemicals which may include fatty acids, sterols, alkaloids, flavonoids, glycosides , saponins , tannins and terpenes as well as other small molecules such as peptides and oligosaccharides . -- It is often difficult to determine which component, if any of the herb has biological activity in humans. Adulteration of herbal products can be made in various ways; commonly, adulteration is made by substituting other easily available or cheap plant species or sometimes by spiking of a product with synthetic constituents. 1 March 2019 14

15. Contd … In addition, the processing of herbs, such as heating or boiling, may alter the dissolution rate, or even the functional activity of the organic constituents. Similarly , a host of environmental factors, including soil, altitude, seasonal variation in temperature, atmospheric humidity, length of daylight, rainfall pattern , shade, dew, and frost conditions, may affect the levels of components in any given batch of an herb . Other factors, including insects, planting density, competition with other plant species, seeding time, and genetic factors , play an important role . Plant collection for the use in botanicals is one of the factors of concern for quality . Plants collected in the wild may include non-targeted species, especially either by accidental substitution or intentional adulteration. 1 March 2019 15

16. References : Joshi LS and Pawar HA, (2015) “Herbal Cosmetics and Cosmeceuticals : An overview ” Natural Product Chemistry and Research 3:170 Thillaivanan.S , Samraj.K . (2014) “Challenges, Constraints and Opportunities in Herbal Medicines – A Review” International Journal of Herbal Medicine 2:21-24 Siri Sindhura D.K , Vikas Jain (2018) “Challenges in formulating Herbal Cosmetics – a Review” International Journal of Applied Pharmaceutics 10:47-53 http://chemistscorner.com/3-challenges-to-formulating-natural-products / http :// edherbalcare-blog.logdown.com/posts/3903821-challenges-facing-form-cosmetics-companies 1 March 2019 16

17. 1 March 2019 17 THANK YOU