•SIGNS AND SYMPTOMS
1.There is abrupt onset of vomiting and
purging of large amounts of rice water
stools (up to 1L/h).
2. Thirstiness
3. Sunken eyes and cheeks .
4. Tachycardia.
5.Hypotension, Oliguria, Muscular cramps,
convulsions , coma , apathy, atrophy.
REPORTED CASES
The number of cholera patients worldwide is
uncertain because most cases go unreported.
Thenumberofcasesisincreasedduring
epidemics&isaffectedbyenvironmental
factors.
AGENT FACTORS
Resistance:-v. cholerae are killed within
30 minutes at 56 deg.C, or few sec. by
boiling
Remain in ice for 3-4 weeks or longer
Drying & sunshine will kill them in few
hours
Disinfectant kill them also
RESERVOIR OF INFECTION
Human is the only known reservoir of
cholera infection
The ratio of severe cases to mild ones is
shown to be 1:5 for classical type & 1:25
for EL Tor
TRANSMISSION
Cholera is transmitted by the fecal-oral route
through contaminated water & food.
Theinfectiousdoseofbacteriarequiredto
causeclinicaldiseasevarieswiththesource.If
ingestedwithwaterthedoseisintheorderof
10
3
-10
6
organisms.Wheningestedwithfood,
fewerorganismsarerequiredtoproduce
disease,namely10
2
-10
4
.
Person to person infection is not
so common.
CLINICAL PICTURE
Incubation period is 24-48 hours.
Symptomsbeginwithsuddenonsetofwatery
diarrhea,whichmaybefollowedbyvomiting.
Feveristypicallyabsent.
Thediarrheahasfishyodorinthebeginning,
butbecamelesssmelly&like“ricewater”in
fewhours.
Inseverecasesstoolvolumeexceeds250
ml/kgleadingtoseveredehydration,shock&
deathifuntreated.
CHOLERA IN CHILDREN
Breast-fed infants are protected.
Symptoms are severe & fever is frequent.
Shock, drowsiness & coma are common.
Hypoglycemia is a recognized complication,
which may lead to convulsions.
Rotavirus infection may give similar picture.
Management
The primary goal of therapy is to replenish
fluid losses caused by diarrhea & vomiting.
Fluid therapy is accomplished in 2 phases:
rehydration and maintenance.
Rehydrationshouldbecompletedin4
hours&maintenancefluidswillreplace
ongoinglosses&providedailyrequirement.
DRUG THERAPY
Thegoalsofdrugtherapyaretoeradicate
infection,reducemorbidityandprevent
complications.
Thedrugsusedforadultsinclude
tetracycline,doxycycline,cotrimoxazole&
ciprofloxacin.
Forchildrenerythromycin,cotrimoxazole
andfurazolidonearethedrugsofchoice.
DRUG THERAPY/2
Drugtherapyreducesvolumeofstool&
shortensperiodofhospitalization.Itisonly
neededforfewdays(3-5days).
Drugresistancehasbeendescribedinsome
areas&thechoiceofantibioticshouldbe
guidedbytheseresistancepatterns.
Antibioticshouldbestartedwhencholerais
suspectedwithoutwaitingforlabconfirmation.
PREVENTION
Education on hygienic practices.
Provision of safe, uncontaminated water to
the population.
Antibiotic prophylaxis to house-hold
contacts.
Vaccination against cholera.
PREVENTIVE MEASURES
CHOLERA VACCINES
Theoldkilledinjectablevaccineisobsolete
nowbecauseitisnoteffective.
Two new oral vaccines became available in
1997. A Killed & a live attenuated types.
Both provoke a local immune response in
the gut & a blood immune response.
Cholera vaccination is no more required
for international travelers coz risk is small.
Currently there are three WHO pre-qualified
oral cholera vaccines (OCV): Dukoral®,
Shanchol™, and Euvichol-Plus®. All three
vaccines require two doses for full protection.
Dukoral®is administered with a buffer
solution that, for adults, requires 150 ml of
clean water. Dukoral can be given to all
individuals over the age of 2 years. There
must be a minimum of 7 days, and no more
than 6 weeks, delay between each dose.
Children aged 2 -5 require a third dose.
Shanchol™and Euvichol-Plus®have the
same vaccine formula, produced by two
different manufacturers. They do not require
a buffer solution for administration. They are
given to all individuals over the age of one
year. There must be a minimum of two
weeks delay between each dose of these
two vaccines
WHO Guidelines
Step (1) : Assess degree of dehydration
Step (2) : Rehydrate the patient &
monitor signs frequently
Step (3): Maintain hydration
Step (4): Administer oral antibiotics to
patient with severe dehydration
Step (5): Feed the patient
:-
CONTROL MEASURES
Steps of epidemic control
Verification of the diagnosis
Early case finding & tracing source of
infection.
Establishment of treatment centers
Notification of the case to MOH & WHO.
Isolation & barrier nursing is indicated
KEY MESSAGE
Achieving national commitment from
water, sanitation and hygiene
(WASH) and health stakeholders to
strongly engage in comprehensive
strategies to eliminate cholera.
SUMMARY
Introduction
Sign and symptoms
Epidemiology
Distribution
Factors
Reservoir of infection
Transmission
Management
Preventive measures
WHO guidelines
Control measures
Programs and Key message
BIBLIOGRAPHY
BT Basavanthappa
Shyama D mala
I Clement
www.wikipedia.org
www.who int
scholar.google co.in