Final Transplantation.ppt transplantation

transplantation in humans. all the relevant pictures and data.

1. Transplantation

7. Organ Transplantation

10. Graft Acceptance and Rejection

11. IMMUNOSUPPRESSIVE THERAPY
OF ALLOGRATFT REJECTION
Non-specific
Specific
Therapy for allograft rejection

12. NON-SPECIFIC
IMMUNOSUPPRESSIVE AGENTS

13. SPECIFIC
IMMUNOSUPPRESSIVE AGENTS
•Suppression of T-cell activity by monoclonal antibodies
•Blocking co stimulatory signals

14. GRAFT VS HOST DISEASE
(GVDH)
Acute GVD occurs within 8-10
days, Chronic GVD can take
upto 3 months
Agents that suppress
cytokine production is
effective in treating GVD

15. Immunologically privileged sites
•Tolerate graft without rejection response
–Lack or dearth of blood/Lymphatic vessels
(cornea)
•Eg
–Brain
–Anterior chamber of eye
–Uterus
–Testes

16. Experimental approaches to
Tissue typing
•Mixed leukocyte reaction
–One way
–Two way
•HLA Typing

17. Mixed Leucocyte reactions
(MLR)
•MHC Molecule rec.
by Tc cells
•Tc cells need
–MHC –peptide
–Costim. signal

18. Tissue Typing

19. Tissue Typing