GPAT MCQ discussion with answer and discussion of answer

these are the pattern of gpat mcq where mostly or frequently asked questions have been discussed. here mostly pharmaceutics portion have discussed due to core subject it makes the important part of pharmacy.

1. Mcq for GPAT 2025 with answer Pharmaceutics

2. 1. If the angle of repose for the given powder is 25-30 degree ,the type of flow is: a. Excellent b. Good c. Passable d. Very poor Answer _ Good

3. 2. Which one of the following is a solid dosage form excipient which can play the role of a diluent a disintegrator a glidant a lubricant and a pore channel former - Lactose Microcrystalline cellulose Ethyl cellulose Eudragit RL 100 Answer – microcrystalline cellulose

4. 3.In capsule making the Bloom strength of gelatin is proportional to molecular weight of the gelatin and is a measure of the [GPAT 2020; AMCP-2022] (a) Cohesive strength of the solvent molecules (b) Cohesive strength of the cross linking that occurs between gelatin molecules (c) Adhesive strength of gelatin with dipping pins (d) Adhesive strength of gelatin with other polymer Ans:-(b) Cohesive strength of the cross linking that occurs between gelatin molecules

5. 4.The sweetening agent commonly used in chewable tablet formula is [ODISHA PHARMNWR RAJASTHAN-2012, ISRO-2017, OSSSC-2021, GATE (a) Sucrose (b) Cyclamate Sodium (c) Saccharin Sodium (d) Mannitol Ans_ (d) Mannitol

6. 5.Lactose is the most widely used diluent in the tablet formulation. However, it is not used in the formulation of one of the following [GATE 1991] a) Pyrazinamide (b) Ibuprofen (c) Sulfacetamide (d)  Isoniazide Answer - (d)  Isoniazide

7. 6.The parenteral product must be [Gujarat DI recruitment Exam 2010; GPAT 2014 ](a) Packed in bottle (b) Sterilized (c) Free from viable/living organism (d) Pyrogenic Ans - (b) Sterilized

8. 7.Parenteral administration [MAHARASHTRA PORE-2021] a) Cannot be used with unconsciousness patients (b) Generally, results in a less accurate dosage than oral administration (c) Usually produces a more rapid response than oral administration (d) is too slow for emergency use Ans - (c) Usually produces a more rapid response than oral administration

9. 8.For intramuscular injection, angle of administration is.................Degree [GPAT 2013] (a)30 (b) 45 (C) 60 (d) 90 Ans- (d) 90

10. 9. Choose the wrong statement from the following with regard to Amorphous solids [GPAT-2020] a) Usually they are anisotropic (b) They tend to flow when subjected to sufficient pressure (c) they do not have definite shape (d) They do not have definite melting point Ans _ a) Usually they are anisotropic

11. 10. Match the following method for particle size determination Method [P] Optical microscope [1] 0.2-100µm [Q] Mechanical Shaker [II] 1-200µm [R] Anderson Pipette [III] 0.5-500μm [S] Coulter-Current [IV] 50-1500µ Choose the correct combination [P] [III], [Q] [IV], [R] [I], [S] [II] (b) [P] [I], [Q] [IV], [R] [II], [S] [III] (c) [P] [I], [Q] [III], [R] [II], [S] [IV] (d) [P] [IV], [Q] [III], [R] [I], [S] [11] Ans- (b) [P] [I], [Q] [IV], [R] [II], [S] [III

12. 11.The ratio of the void volume to the bulk volume of the packing of the powder is called as[GATE-2005] (a) Porosity (b) True density (c) Granular density (d) Bulk density Ans - (a) Porosity

13. 12 What is the Schedule for Ophthalmic preparation A M Y FF Ans- d FF

14. 13. What type of glass is not used for parenteral preparation - Highly resistant borosilicate glass Treated sodalime glass Soda lime glass General purpose soda lime glass Ans – d. General purpose soda lime glass

15. 14. When is a NDA made? A. Once the animal studies are done and drug is declared safe in animals. B. Once the animal studies are done and drug declared safe and effective in animals study. C. After the phase III clinical trial. D. After the phase IV clinical trial . Ans – C. After the phase III clinical trial .

16. 15 Which of the following is not a method for solubility enhancement: Crystallization Co-solvency Salt formation Hydrotropy Ans – A. Crystallization Crystallization is not a method for solubility enhancement. In fact, crystallization is typically used to purify compounds and reduce solubility in a solvent. In contrast, co-solvency, salt formation, and hydrotropy are methods used to improve the solubility of poorly soluble drug

17. 16.Schedule T of Drugs and Cosmetics Rules, 1945 deals with: GMP for ASU drugs GLP and requirement of premises and equipments GMP for Homeopathy medicine GMP for Pharmaceutical product Ans – a. GMP for ASU drugs Schedule T of the Drugs and Cosmetics Rules, 1945 deals with the Good Manufacturing Practices (GMP) for Ayurvedic, Siddha, and Unani (ASU) drugs. It sets out the requirements for the manufacturing, storage, and distribution of these traditional medicines to ensure their quality and safety .

18. 17. Core tablet coated with cellulose acetate phthalate has been administered to a patient. Where do you expect the drug to be released : a . Liver b. Intestine c. Oral cavity d. Stomach Ans - b. Intestine Cellulose acetate phthalate (CAP) is a pH-sensitive coating that is designed to dissolve in the intestine, which has a higher pH compared to the stomach. This allows the drug to be released in the intestine, avoiding degradation in the acidic environment of the stomach .

19. 18. The bloom strength is directly proportional to: a. Measure of the strength and stiffness of the gelatin b. Density c. Molecular weight d. Viscosity Ans- c. Molecular weight Bloom strength is directly proportional to the molecular weight of the gelatin. The higher the molecular weight, the more intermolecular forces there are between the polymer chains, leading to a stronger and stiffer gel. As the molecular weight increases, the gelatin network becomes more rigid, which increases its ability to hold the structure and hence results in higher bloom strength.

20. 19. Which of the following climatic zones can be categorized into the hot and dry zone? Zone-II Zone-I Zone-III Zone-IV Answer – 3. Zone-III

21. 20. Which of the following mills is based on the mechanism of impact and attrition for size reduction: a. Roller mill b. Fluid energy mill c. Hammer mill d. Colloid mill Ans- b. Fluid energy mill

22. Roller mill – principle of shear force

23. 21. Autoclave work on the mechanism of - Oxidization of protein denaturation of cell wall Coagulation of protein Cellular changes Ans – C. Coagulation of protein

24. 22.Which of the following is a causative organism for Syphilis: Vibrio cholerae Treponema pallidum Bacillus pertussis Clostridium tetani Ans – 2. Treponema pallidum

25. 23. HLB value of detergent A. 1-3 B. 3-8 C. 16-18 D. 13-16 Ans - D. 13-16

26. 24. Sparingly soluble term is for - A. 0-10 B. 10-30 C. 30-100 D. 100-1000 Ans.- C. 30-100

27. 25. Primary purpose of penetration enhancer - To accelerate metabolism To increase the rate of drug absorption To reduce drug toxicity To enhance taste Ans – b. to increase the rate of drug absorption