Immunity pfd for 1st year student Bams Mbbs

Description of immunity

1. IMMUNITY
Presented By
Dr RenukaIKKarPatil

2. IMMUNITY
Capacity of body to resist the pathogenic agent
Ability of body to resist the entry of different
types of foreign bodies like bacteria ,virus,toxic
substances etc

3. IMMUNITY

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9. « 1* Line of Defense | + Slower response
' + Non-specific + Specific
la 2 + Rapid Response + Memory
y + No Memory
fi à
그 ¿ Components Components
* Complement ・ Antibodies
« White Blood cells: [| + B cells
Macrophages Helper T cells
Neutrophills Killer T cells
し Natural Killer cells Dendritic cells

10. Innate Immunity/Non Specific/Natural
•Inborn capacity of body to resist the pathogens.
•First line of defense

15. Acquired Immunity/Specific
Resistance developed in the body against any
specific foreign body
Lymphocytes –responsible
Types-2
I.Cellular
II.Humoral

18. T Lymphocytes-4 types

clones of T cell killer T cell
T call O destroys virus-infected cell
©— O— © O helperT cell
boosts immune response by
activating killer T cells and

© stimulating antibody
production by B cells

virus-infected cell
memory T cell
persists in bloodstream lo

suppressorT cell protect against future infections
protects healthy cells

19. B Lymphocytes

B cells

・ Humoral response = “in fluid”
— defense against attackers circulatin
freely in blood & lymph
・ Specific response
— produce specific antibodies
against specific antigen
・ Types of B cells +
ㆍ plasma B cells

— immediate production of antibodies
— rapid response, short term release

-一 了 * memory B cells

— long term immunity

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21. Storage of T& B lymphocytes
Storage-
-stored in lymphoid tissues of lymph nodes
spleen,bonemarrow and GI tract

22. Antigens

Antibody

Antigen

An antigen is a substance
that induces the formation
of antibodies because

it is recognized by the
immune system as a threat

Red blood cell

ADAM.

25. Development of cell mediated Immunity
Developed by cell mediated response
Does not involve antibodies
Involves several types of cells such as
macrophages,tlymphocytes,naturalkiller cells
Cellular immunity/T cell immunity
Against infectionsbyviruses,fungi,bacteria(T.B)

26. Development of cell mediated Immunity
•Invading microbial organism carry the antigenic
materials
•Antigen presenting cells
•Helper T cells

76. INTERFERONS

© | Endätheliäl.ceit |

aS Y Ÿ … > Activation
Activation o

& =.

Macrophage >
Y

DO @

Increase in NK
Call activity

2

Weak anti-viral activity 리에 of cave 1001
Stops cell division Differentiation
Hematopoiesis stops T cell activation Stops cell division

78. Defensins

DEFENSIN FUNCTIONS
(1) Defend from pathogens
(2) Shape microbiota

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(3) Protect stem cells

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guage OO To TO A

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& - Defensins
へ - Bacteria