Immunologic memory

immunology topic

1. Dr Ashish Warghane PhD
Department of Life Sciences,
Mandsaur University,
Mandsaur, Madhya Pradesh,
India. Pin: 458 001
Mob:[phone]
Email:[email protected]
IMMUNOLOGICAL MEMORY

2. Immunologicalmemoryistheabilityoftheimmunesystemto
quicklyandspecificallyrecognizeanantigenthatthebodyhas
previouslyencounteredandinitiateacorrespondingimmune
response.
Generallythesearesecondary,tertiaryandothersubsequent
immuneresponsestothesameantigen.
Immunologicalmemoryisresponsiblefortheadaptiveimmune
system,specialTandBcells—theso-calledmemoryTandBcells.
Immunologicalmemoryisthebasisofvaccination.
Immunological memory

3. Immunologicalmemoryoccursafteraprimaryimmuneresponse
againsttheantigen.
Immunologicalmemoryisthuscreatedbyeachindividual,aftera
previousinitialexposure,toapotentiallydangerousagent.
Thecourseofsecondaryimmuneresponseissimilartoprimary
immuneresponse.
AfterthememoryBcellrecognizestheantigenitpresentsthe
peptide:MHCIIcomplextonearbyeffectorTcells.
Thatleadstoactivationofthesecellsandrapidproliferationofcells.
Aftertheprimaryimmuneresponsehasdisappearedtheeffector
cellsoftheimmuneresponseareeliminated.
Development of immunological memory

5. Inadditiontotheformedantibodiesinthebodythereremainsa
smallnumberofmemoryTandBcellsthatmakeupthecellular
componentoftheimmunologicalmemory.
Theystayinthebodyinarestingstateandatthesecondornext
encounterwiththesameantigenthesecellsareabletorespond
immediatelyandeliminatetheantigen.Memorycellshavealong
lifeandlastuptoseveraldecadesinthebody.
However,thereremainantibodiespreviouslycreatedinthebody
thatrepresentthehumoralcomponentofimmunologicalmemory
andcompriseanimportantdefensivemechanisminsubsequent
infections.