Flx Case Study
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672 Current Alzheimer Research, 2014, 11, 672 680
Fluoxetine Improves Behavioral Performance by Suppressing the Production of
Soluble Amyloid in APP/PS1 Mice
Abstract: Alzheimer s disease (AD) is the most common neurodegenerative disorder
of the central nervous system. Cur
rent approaches for AD treatment only ameliorate symptoms. Therapeutic strategies
that target the pathological processes
of the disease remain elusive. Fluoxetine (FLX) is one of the most widely used
antidepressants for the treatment of de
pression and anxiety associated with AD, however, it is unknown if the drug affects
the pathogenesis of the disease. We
showed that FLX improved spatial ... Show more content on Helpwriting.net ...
Although most cases of AD are sporadic in nature, about 5 10% result from an
inherited familial form caused by the expression of mutant genes of amyloid
precursor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2) [3].
Despite recent advances in the understanding of the pathophysiology, there are no
medical approaches that can cure AD. All current medications available for the
treatment of the disease only improve the symptoms of AD to varying
*Address correspondence to these authors at the Mental Health Center
Shantou University, North Taishan Road, Shantou, Guangdong 515063,
China; Tel: 86 0754 82902014; Fax: 86 0754 82510525;
E mail:
[email protected] and Department of Psychiatry, Faculty of
Medicine and Dentistry, University of Alberta, 1E7.31 Walter C. Mackenzie
Health Sciences Centre, Edmonton, Alberta, Canada T6G 2B7;
Tel: 1 780 407 6503; Fax: 1 780 407 6804; E mail:
[email protected]
#These authors contributed equally to this work.