IPP chapt-10.pdfsuspension for regular class

yisihakchalachew 54 views 53 slides Jun 08, 2024
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About This Presentation

Ipp unit 10


Slide Content

Rete Gender
ee dal of depend phase (ictereal phan) range from

i Types Of Emulsions:

Diluted with Diluted with

Water
No Phase Phase Change

| one 7

Diluted with Diluted with
Mater a

— as | >

Phase Change

WO Emulsion WO Emulsion WO Emulsion

OWEmuislon ‘OW Emulsion OW Emulsion

jotivity Test:

3—Bulb does not

[sem

‘Beaker —

Electrodes

OF

Tests Used To identify Emulsion Type:

1 Dye-Solubility Test:

Aqueous Liquid
'Cantinuous Phase) eer

Organic Solvent
(Bropiet Phase)

Mechanism of action of emulsifying

Film of emulsifier

2
2
5
<

Diagrammatic Representation of the Films Formed by the Emulsifying Agent at the
o/w Interface.

ln, hi

Emulsion W/O (Water / Oil) Emulsion O/W (Oil / Water)

emulmiying
A-These trom vegetable sure

1-hater agent may be coqs inte tros groves:

B-Tbsse bem ciel see

2- Finely divided solid:

3- Syniheiis emulsifying agents as

Alkali song:

Gationic surfacionte

5. Cay! timethyiammanium bromide (Ceirinide)
aed bencahonue ehignde

1 Disadvaniagos:
|

Table Ill: HLB Number vs. Solution Function

ME Wterlileruisiers |

; Calculation of HLB:
Srita equation:

On small scale:

Proportions of:
O eee er |

Volatile oil

1 Continental or dry gum method:

|
;

|

ı English or Wet Gum Method

I
y

|

|
|
|

Emulsion Stability:

The instability of pharmaceutical emulsions
may be classified as the following:

Physical Stability Mechanisms

Stable
Emulsion

Zu

Gravitational Coalescence Phase
Separation or Separation
Flocculati

Ti

Ostwald
Ripening

ion

i. Coalescence Se A ii. Flocculation

Y N
ö Good
Emulsion

iii. Creaming iv. Breaking

i nee and creaming:

flats \"

1 Stoke's equation included the factors that
affect the creaming process:
dx/dt = d2 (pi-pe)g/18n

eve velocity upward creaming ]
pipe =+ve [ downward creaming]

pr

prpe = -ve [i

Ona, However tipo is applied.
AV 1 dome

Definition

Reverersability

Agitation

Emulsifying
film around

particles
Internal phase

globules
Effect of phase
volume ratio

li may be brought abect by:
ale ompision formed by salon siceraio ean bo inveried le
we.

Phess ungen con be mama by:

| Graskieg al emulsion aan be due ta:

eg. Monovalcal soup + divalent emp
00. acignia + calins enuisiying agent

ey dal coop: dosemperod by acs
eq. neneveiost compe cated aut by olontralptos much us
Gg. memes emulsifying agonía we nonmpatnie wah

es, aloshal precigtiaies gums and gelaiin

eg aires of u Savon m whieh to we PRESSE eo
aaishic (alaba)

Preservation from microorganisms:

; methyl, propy! and Duty! parabens
exalta

1 on from oxidation:

ı @g-butyiaiod hydrozyanisolo (BHA)
e.g-buiyiaied hydroryioluene (BHT)

1. Determination of particle size and particie
count:

- In case of ofw emulsions

- In use of w/o emulsiones

EAN

e RI ess ns

siabiiiy of emulsions:
1- Aging and iemperaiure



- Freezing damage emulsion more than heating ?

Flocculation b

Coalescence

ence a cc

| or liquid crystal
‘Surfactant
aggregates:
oil
Water
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