Latuda m. dixon

PowerPoint
Advanced Pharmacology
MSNE 5356

1. Marian Dixon, Lamar University Advanced Pharmacology MSNE 5356 Dr. Elizabeth Long LATUDA (lurasidone HCl)

2. Major Tranquilizer Second Generation - Antipsychotic drug - Neuroleptic Approved by the FDA to treat: 2010 Schizophrenia 2013 Bipolar Disorders Drug Chosen: LATUDA (Lurasidone HCl) This Photo by Unknown Author is licensed under CC BY-SA-NC ( Fala , 2014)

3. Psychosis: Symptom of psychiatric and physical illness Loss of reality -Unable to discern what is real Hallucinations (auditory) Disordered speech, thoughts and actions Lack of concentration to catatonia Aggressive to themselves or others Anxiety - Depression - Obsessive thinking Sleep disorders Delusions of paranoia and or grandeur Pathophysiological Conditions Treated with Latuda (MacGill,2017)

4. Calms patient experiencing psychotic symptoms Blocks receptors for neurotransmitters Dopamine Serotonin (National Center for Biotechnology Information, 2015) Intended Response of Latuda This Photo by Unknown Author is licensed under CC BY-SA

5. Potential Interactions with Latuda Latuda is metabolized by CYP3A4 enzymes Strong CYP3A4 inhibitors or inducers Ketoconazole Nizoral Xtina Xolegel Rifampin Warfarin Grapefruit This Photo by Unknown Author is licensed under CC BY-SA (Psychopharmacology Institute, 2018)

6. Elderly Patients increased cerebrovascular adverse events Neuroleptic Malignant Syndrome Tardive Dyskinesia Metabolic Changes/Weight Gain Hyperglycemia/Diabetes Mellitus Dyslipidemia Suicidal thoughts Leukopenia Dizziness Adverse Reactions (Psychopharmacology Institute, 2018)

7. Side effects may be different for each individual Suicidal thoughts (esp. children, teens and young adults) Akathisia ( restlessness) Nausea Weight Gain Insomnia (MacGill,2017) Side Effects

8. Therpeutic Peak – 1 to 3 hours Absorption 9% to 19% Two or three times absorption when taken with food of at least 350 calories 99% Bound by serum proteins Metabolized by the liver Half-Life is 18 – 40 hours depending on dose Excreted 80% feces and 9% urine (Psychopharmacology Institute, 2018) Pharmacokinetics of Latuda

9. Diltiazem Erythromycin Diflucan Cause increase of Latuda’s blood levels Carbamazepine Phenobarbitals Warfarin Cause decrease of Latuda’s blood levels (National Alliance on Mental Illness, 2018) Drug Binding Issues with Latuda

10. Improving Communication Benefits 1. Improved Patient Outcomes 2. Improved Patient Satisfaction 3. Reduced Healthcare Costs Collaboration 1. Imparting/Interchange of thoughts 2. Complementary Roles 3. Cooperation/Working together 4. Shared Problem Solving 5. Formulate and Carry-Out Plans ( Zysk , 2018)

11. In-services for Nursing Staff Pre/Post-Test of common medications Physicians discussing medications Collaborative Communication Skills Shared Problem Solving and Planning Transitioning from Team to Primary Care Model of Nursing Application to the Practice Setting

12. Fala , L., (2014). Latuda (Lurasidone HCl) receives 2 new indications for use in bipolar depression as monotherapy and as adjunctive therapy with lithium or valproate. American Health & Drug Benefits. 7Retrieved November 30, 2018 from http://www.ahdbonline.com/issues/2014/march-2014-volume-7-special-feature-fifth-annual-payers- guide-to-new- fda -approvals/1721-latuda-lurasidone-hcl-receives-2-new-new-indications-for-use-in-bipolar- depression-as-monotherapy-and-as-adjunctive-therapy-with-lithium-or-valproate Latuda.com (2018). Retrieved November 26, 2018 from https://www.latuda.com/bpd/side-effects-of- Latuda.html?utm_medium= SEM&utm_source = google&utm_campaign = LATUDA+Consideration&utm_term =%Bside%20%2Beffects%20ofof%2B1HjK_EWE_ H89xqkHL.ckrXReR61u3Qp8nzdoQhqTCxPfhM88asaAkGIEALw_wcB&gclsrc=aw.ds MacGill , M., (2017). Psychosis: Causes, symptoms, treatments. Retrieved November 10, 2018 from https://www.medicalnewstoday.com/articles/2481.59php National Alliance on Mental Illness. (2018). Retrieved November 10, 2018 from https://www.nami.org/Learn-More/Treatment/Mental-Health-Medications/ Lurasidones-(Latuda) References

13. National Center for Biotechnology Information (2015, February 02). Lurasidone (Latuda) for schizophrenia: Overview. Retrieved November 10, 2018, from https://www.ncbi.nlm.gov/books/NBK303986/ Psychopharmacology Institute (2018). Retrieved November 11, 2018 from https://psychopharmacology i nstitute.com/antipsychotics/lurasidone/lurasidone- pharmacokinetics/ Zysk , T., (2018). Three ways collaborative communication technology improves healthcare delivery. Retrieved November 26, 2018 from https://www.liveprocess.com/blog-three-ways-collaborative-communication-improves- healthcare/ References