MECHANISM OF VASCULAR EVENTS OF INFLAMMATION.pptx

Vascular event of inflammation made easy to understand with illustrated figures

1. VASCULAR EVENTS OF INFLAMMATION MEDICO MENTOR 1

2. INTRODUCTION MEDICO MENTOR 2

3. STEPS OF VASCULAR EVENT OF INFLAMMATION ARTERIOLAR DILATION Due to chemical mediators : Histamine, Nitric oxide etc. Results in : Increased hydrostatic pressure MEDICO MENTOR 3

4. STEPS OF VASCULAR EVENT OF INFLAMMATION 2) INCREASED VASCULAR PERMEABILITY AT THE VENULE SIDE Due to chemical mediators : Histamine, Kinins , leukotrienes, Prostaglandins etc. Results in : 3) LEAKAGE OF FLUID AND PROTEIN (Albumin mainly)into the interstitium . Decreased colloid osmotic pressure MEDICO MENTOR 4

5. STEPS OF VASCULAR EVENT OF INFLAMMATION INCREASED HYDROSTATIC PRESSURE (DUE TO INCREASED BLOOD FLOW FROM THE ARTERIOLE END) INCREASED VASCULAR PERMEABILITY DECREASED COLLOID OSMOTIC PRESSURE (DUE TO LEAKAGE OF ALBUMIN INTO THE INTERSTITIUM) FLUID ESCAPES FROM INTRAVASCULAR SPACE INTO THE INTERSTITIAL SPACE (Edema) MEDICO MENTOR 5

6. FLUID ESCAPES FROM INTRAVASCULAR SPACE INTO THE INTERSTITIAL SPACE (Edema) RBCs aggregate into rouleaux (stacked coins) in venules Neutrophils are pushed from the central axis column to the periphery ( Margination , the first step of cellular events of inflammation….) MEDICO MENTOR 6

7. Thank you……coming soon……Cellular events of inflammation…… MEDICO MENTOR 7