Meconium is passed into amniotic fluid when fetal distress and anoxia have occurred in utero The skin may be stained with meconium and the infant is depressed During gestation or with the first breath, thick meconium is aspirated into the lungs
Airway obstruction with in a few hours after the birth Respiratory distress ( tachypnea , grunting, cyanosis) Resuscitation (infant)- pneumothorax Over expansion and rupture of alveoli Atelectasis