Medicinal Chemistry II Course Syllabus.docx

WSU, School of Pharmacy

1. Medicinal Chemistry II Course Syllabus
Course Title: Medicinal Chemistry II
Course Code:Phar3141
Course EtCTS: 5
Pre-requisite: Medicinal Chemistry I
Co-requisite:Pharmacology II
Course Description
Medicinal Chemistry II is a continuation of medicinal chemistry I & covers; Diuretics and
Cardiovascular agents, Chemotherapeutic agents which includes Antiseptics and Disinfectants,
Preservatives, Antifungal agents, Antitubercular and Antileprotic agents, Topical agents,
Antiviral agents, Antiprotozoal drugs, Anthelmintics, Antiscabies & Antipedicular agents,
Sulfonamides, Antibiotics & Anticancer drugs; and Steroidal and Non Steroidal and related
drugs.
Course Objectives
After completion of this course, students will be able to understand drugs that will act on the
kidney, cardiovascular system, drugs used for treatment of infectious diseases, vitamins and
hormones.
Course Content
1.Diuretics and Cardiovascular Drugs
o Diuretics
oAntianginal agents and vasodilators
oAntihypertensive agents
oDrugs used for treatment of congestive heart failure
oAntiarrythmic drugs
oAnti-anemic Agents
oDrugs for Hypotensive States
oAntihyperlipidemic drugs
oCoagulant and anticoagulants
2.Oral hypoglycemic Agents
3.Chemotherapeutic Agents
o Introduction
o Antiseptics & disinfectants
oPreservatives
o Antibacterial agents and related drugs
Introduction
-lactam antibiotics and Glycopeptides
The amino glycosides
The tetracyclines
The macrolides
Chloramphenicol
Sulfonamides and related drugs

2. Quinolones
The polypeptides, polyenes and lincomycin
Antitubercular & Antileprotic agents
Antimicrobial topical agents
Other antibacterial agents
o Antifungal agents
oAntiprotozoal agents
Antimalarial drugs
Drugs used in amebiasis, giardiasis & trichomoniasis
Drugs used in other protozoal infections
oAnthelmintic agents
oAntiscabies & Antipedicular agents
oAntiviral agents
Anti-HIV agents
Other antiviral drugs
oAntineoplastic agents (5 hr.)
Chemotherapy
Alkylating agents
Antimetabolites
Antibiotics
4.Vitamins and Coenzymes
o Fat-soluble vitamins
o Water-soluble vitamins
o Co-enzymes
5.Non Steroidal Hormones and Related Drugs
o Hormones of the hypothalamus
o Pituitary hormones
o Thyroid hormones and anti-thyroid drugs
o Parathyroid hormones
o Pancreatic hormones and related drugs
6.Steroidal Hormones and Related Drugs
o Male and female sex hormones, derivatives and related drugs
o Adrenocorticoids
Mode of Assessment
-Quizzes (10%)
-Tests (30%)
-Seminars and Assignments (20%)
-Final Exam (40%)

3. Text Book
Lemke, T.L. and Williams, D.A., Roche, V. F., Zito,W.S.Foye’s Principles of Medicinal
Chemistry, 6th. ed. Lippincott Williams & Wilkins, 2008.
-Wilson-Gisvold-Doerge; Text book of organic medicinal chemistry and pharmaceutical
chemistry. 12
th
edn.; Lippincott (USA), 2011.
-Carmen Avendano and J. Carlos Menendez, Medicinal Chemistry of Anticancer drugs, first
edition, 2008
-Donald J. Abraham (Ed.). Burgers’s medicinal Chemistry and Drug Discovery, 2006, 6th
edn., vol1-6, wiley-interscience (USA).
-J.H. Block and J.M. Beale, Gisvold, O. Wilson & Gisvold’s Textbook of Organic Medicinal
and Pharmaceutical Chemistry, 11th. ed. Lippincott Williams & Wilkins, 2004.
-Burger's Medicinal Chemistry and Drug discovery, Sixth edition, Volume 3: Cardiovascular
Agents and Endocrines; 2003
-Burger's Medicinal Chemistry and Drug discovery, Sixth edition, Volume 5:
Chemotherapeutic Agents; 2003