Objectives - Describe the functions of water in the body. - Explain fluid balance and its maintenance. - Name the causes and consequences of water depletion. - Give some causes and consequences of positive fluid balance. - Describe the acid-base balance in the human body.
Functions of water 1- Major component of blood plasma 2- Solvent for nutrients and waste products 3- Necessary for hydrolysis of nutrients
4- Essential for metabolism 5- Lubricant in joints and digestion 6- Cools the body through perspiration 7- Provides some mineral elements
Sources of water - Drinking water is the best source. - Other beverages are second-best source. - Other sources include fruits, vegetables, soups, milk, and gelatin desserts.
- Energy metabolism produces water. When carbohydrates, fats and proteins are metabolized, their end products include carbon dioxide and water
Estimated Daily Fluid Intake for an Adult - Ingested liquids: 1,500 mL - Water in foods: 700 mL - Water from oxidation: 200 mL - Total: 2,400 mL
Body Fluid Body fluid or body water are divided in to two: 1- Intracellular fluid (ICF): Means within the cells and it equivalent 65% of total body fluid
2- Extracellular fluid (ECF): means outside the cells and it equivalent 35% of total body fluid Found in intravascular fluid (in blood stream) interstitial fluid (between cells) and glandular secretions.
Fluid and Electrolyte Balance: - Sensible water loss is water lost through urine. - Insensible water loss is water lost in feces, perspiration, and respiration. - Waste products of metabolism excreted in the form of urine (500 mL of water each day).
- Solute : is substance dissolved in a solution - Osmosis : water flows from the side with the lesser amount of solute to the side with the greater solute concentration .
- Potassium is the principal electrolyte in intracellular fluid. - Sodium is the principal electrolyte in extracellular fluid . - Sodium , chloride, and potassium maintain the balance between intracellular and extracellular fluids.
Hypothalamus regulation - When electrolytes in ECF are increased, ICF moves to the ECF to equalize the concentration of electrolytes on both sides. - This reduces the amount of water in the cells which causes the cells of the hypothalamus mouth and tongue become dehydrated and cause thirst.
- When cells in the hypothalamus become dehydrated, the hypothalamus stimulates the pituitary gland to excrete ADH (antidiuretic hormone). - ADH causes kidneys to reabsorb water. - And thirst causes a healthy person to drink fluids .
Adrenal Glands regulation - When sodium in ECF is reduced, water flows from ECF into ICF , causing cellular edema. - Adrenal glands secrete aldosterone, which triggers kidneys to increase the amount of sodium reabsorbed. - When sodium is replaced in the ECF, excess water moves back to the ECF and edema is relieved.
Water requirement: - Amount of water use varies, depending on age, size, activity, environmental temperature, and physical condition .
Clinical Conditions Affecting Hydration - Uncontrolled diabetes : - Cystic fibrosis - High fiber intake - High protein intake - Intense physical activity - Impaired thirst in older adults - Medications
Dehydration - Occurs when amount of water in the body is inadequate - Caused by inadequate intake or loss, loss can occur from severe diarrhea, vomiting, hemorrhage, burns, diabetes mellitus, excessive perspiration, excessive urination, or the use of certain medications, such as diuretics.
- Decrease in urine output - Weight loss - Eyes appear sunken - Tongue has increased furrows and fissures - Oral mucous membranes are dry - Decreased skin turgor - Changes in neurological status
Treatment: The treatment involves replacement of electrolytes and fluids.