observational study of socio demographic pattern, risk , prognostic factors of acute CNS infection.pptx

Talks about acute encephalitis syndrome in children

1. SOCIODEMOGRAPHIC PATTERN, RISK AND PROGNOSTIC FACTORS OF ACUTE ENCEPHALIITIS SYNDROME IN CHILDREN PRESENTING TO A GOVERNMENT TERTIARY CENTRE IN CHENNAI A PROSPECTIVE OBSERVATIONAL STUDY ---

2. AIM To describe the demographic pattern of children presenting with acute encephalitis syndrome To describe various risk and prognostic factors To describe eitiological profile of AES

3. objectives To identify geographical clustering of acute encephalitis syndrome cases presenting to a government tertiary care center in Chennai To describe the clinical and etiological profile of children of age group 1 to 12 years presenting with acute encephalitis syndrome. To determine various risk factors for poor neurological outcome

4. Department of Institution where the research will be carried out: Institute of social paediatrics , government stanley medical college

5. Duration of study 1year

6. Sample size All children with the inclusion criteria during the time period shall be enrolled Into the study.

7. Inclusion criteria Children of both gender aged 1 to 12 years presenting with acute onset of fever and a change in mental status (including symptoms such as confusion, disorientation, coma or inability to talk), and/or new onset seizures Fever defined as documented temperature of more than 38 degree Celsius

8. Exclusion criteria Age <1year and age >12 years of both gender Simple febrile seizure Seizure disorder Underlying brain parenchymal disease

9. METHODOLOGY Prospective observational study All patients admitted with acute encephalitis syndrome fitting into the inclusion criteria will be enrolled into the study at admission. Informed consent will be obtained. Children diagnosed with simple febrile seizure , head injury, and underlying seizures disorder and or brain parenchymal disease shall be excluded from the study DATA COLLECTION Data pertaining to the clinical features at admission and progress and complication, the lab results and treatment given shall be obtained from the Emergency room assessment sheet and patient case sheet. Lumbar puncture will be done after obtaining informed consent and CSF analysis will be done. Field visit to the patient’s home shall be conducted and questionnaire will be administered to parents to identify any preventable environmental risk factors . Follow up Patients neurological outcome shall be assessed at discharge , 1week, 2week, 1 month by clinical Assessment. Patient shall be followed up at 2 months by phone call

10. Results Total children enrolled 10 Fch 4 Mch 6 40% 60%

11. Age wise distribution

12. Seasonal variation

13. Clinicalfeatures Fever duration

14. Neurological symptoms and signs

15. Seizure pattern single episode 2 multiple episodes 3 febrile status 4 refractory status 1

16. Duration of hospital stay

17. Eitiology

18. Outcomes Ventilated case 1 Death 1 Discharged 9 Residual neurological defects 2 Behavioral problem 1 Discharged on antiepileptics 4