OP Poisoning presentation

this slide is for medicos students

1. Organophosphate poisoning Dr. Swati Rai Assistant Professor Department of Pharmacology & Therapeutics

2. Specific Learning Objectives Introduction Pathophysiology Sign and symptoms Management Prevention

3. Organophosphates Large group of compounds having potential to irreversibly inhibit the cholinesterase's enzymes . Used as insecticides, pesticides and nerve gases

4. Google image Mechanism of action

5. Organophosphate compounds Insecticides – Malathion Parathion Echothiophate Nerve gases – Soman Sarin Tabun Google image

6. Google image Routes of exposure Oral Inhalational Transdermal Transconjunctival

7. Occupational exposure Google image

8. Pathophysiology Organophosphate inactivate acetyl cholinesterase by phosphorylating the acetylcholinesterase enzyme Increase the level of Ach in synaptic cleft. Manifest as muscarinic and nicotinic sign and symptoms

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10. Sign and Symptoms

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12. Nicotinic Effect Fall in BP Muscular fasiculation Weakness Respiratory paralysis Tremor Coma Death

13. Treatment

14. Termination of further exposure to the poison -Fresh air, remove the clothes Wash the skin and mucous membranes with soap and water Gastric lavage Maintain patent airway, positive pressure respiration Supportive measures – Maintain BP, hydration, control convulsions

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16. Specific antidote - Atropine - 2 mg IV repeated every 5-10 min till atropinization - more than 200mg may be required on day one Cholinesterase reactivators- - Pralidoximes 1-2gm IV

17. Prevention

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20. Summary Organophosphate compounds are a diverse group of chemicals used in both domestic and industrial settings Poisoning occurs after dermal, respiratory, or oral exposure It is an irreversible inhibitor of acetyl cholinesterase enzyme Antidote – Atropine

21. Thank you