PATOLA KATUROHINYADI KASHAYA.pptx

DR.AJITH KUMAR
CLINICAL APPLICATION OF PATOLAKATUROHINYADI KASHAYA IN ALD AND SKIN DISORDERS

1. FORMULATION SEMINAR PATOLAKATUROHINYADI KASHAYA Dr.Ajith Kumar Final Year M.D scholar Dept of Rasashastra and Bhaishajya Kalpana KLE SHRI B.M.K.A.M AND HOSPITAL BELAGAVI 1 FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 01-09-2023

2. CONTENT Introduction Objectives Reference Ingredients Indications Contraindications Pharmaceutical aspects Critical analysis of the ingredients FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 2 Application in Clinical Practice Manufacturing companies Researches Discussion Own research views Summary Conclusion 01-09-2023

3. INTRODUCTION Patolakaturohinyadi kashayam is a potent polyherbal formulation useful in the treatment of diseases of the skin and liver. It shows a beneficial effect in the burning sensation, pigmentation, itching, ulcers, etc. It rejuvenates the skin, improves digestion, and protects the liver. It is more commonly used in South Indian ayurvedic practice. FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 3 01-09-2023

4. OBJECTIVES To study the method of preparation of Patolakaturohinyadi kashaya . To analyze the rationality behind its ingredients. Application of Patolakaturohinyadi Kashaya in clinical practice To discuss some of the research works related to this formulation. FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 4 01-09-2023

5. REFERENCE FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 5 01-09-2023 पटोलकटुरोहिणीचन्दनं मधुस्रवगुडूचिपाठान्वितम् | निहन्ति कफपित्तकुष्टज्वरान् विषं वमिमरोचकं कामलाम् || A.H.S-15/15

6. INGREDIENTS FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 6 S.NO. DRUG BOTANICAL NAME PART USED QUANTITY 1. Patola Trichosanthes dioica Whole plant 1 part 2. Katurohini Picrorhiza kurroa Root 1 part 3. Chandan Santalum album Kandsar 1 part 4. Madhusrava ( Murva ) Marsdenia tenacissima Root 1 part 5. Guduchi Tinospora cordifolia Root/stem/ leaves 1 part 6. Patha Cissampelos pariera Root 1 part 01-09-2023

7. INDICATION FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 7 Kamala Kushtha Vamana Aruchi Jwara Vishajanya vyadhi 01-09-2023

8. CONTRA-INDICATION It should be taken with care for diabetic patients if already on medication as it can reduce the levels of sugar very much. FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 8 01-09-2023

9. PHARMACEUTICAL ASPECT- PURVA KARMA FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 9 Collection of ingredients: 01-09-2023 Patola Katurohini Chandana

10. 01-09-2023 FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 10 Murva Guduchi Patha

11. Pharmaceutical aspects - Pradhanakarma (General SOP of Kashaya preparation) All the drugs are converted into coarse powder form in equal quantity. Drugs are taken in a vessel and added with 16 times of water and boiled till reduced to 1/4 th Kashaya is filtered and taken for therapeutic purpose FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 11 01-09-2023

12. Pharmaceutical aspects - Pashchatkarma Filtered and taken for further therapeutic purpose FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 12 01-09-2023

13. Pharmaceutical aspects - Large scale production Drugs are powdered using pulveriser. The powdered drugs are added to the Mass mixer. T he drugs are taken in a large vessel for kwatha preparation. 13

14. Critical analysis of the ingredients DRAVYA RASA GUNA VIRYA VIPAKA DOSHAGNATHA 1. Patola Tikta Laghu Ushna Katu Kaphapittahara 2. Katurohini Tikta Laghu Sheeta Katu Kaphapittahara 3. Chandana Madhura Tikta Laghu Sheeta Katu Kaphapittahara 4. Murva Madhura Tikta Guru Sheeta Katu Tridoshahara 5. Guduchi Tikta Kashaya Guru Snigda Ushna Madhura Tridoshaghna 6. Patha Tikta Laghu Teekshna Ushna Katu Kaphapittahara FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 14 01-09-2023

15. Critical analysis of the ingredients DRUG AYURVEDIC VIEW MODERN VIEW 1. PATOLA Deepana Pachana Jvarahara Dahahara Varnya Kandughna Kushthaghna Raktadoshahara Carminative Blood purifier Anti-helminthic Hepato-protective 2. KATUROHINI Deepana Krimighna, Daha prashaman Kusthaghnas Carminative Anti- helminthic Hepato-protective Anti-diabetic Anti-pyretic 3. CHANDANA Raktaprasadana Dahaprashamana Durgandhahara Coolant, diuretic Antiseptic Anti-microbial 01-09-2023 FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 15

16. Critical analysis of the ingredients DRUG AYURVEDIC VIEW MODERN VIEW 4. MURVA Pramehahara , Kushtha Kandu Hridaya roga Antiscorbutic Anti-oxidant Anti-bacterial Depurative Laxative 5. GUDUCHI Vayasthapana Trishnanigraha Triptighna Dahaprashamana Stanyashodhana Jvaraghna Antipyretic CNS depressant Hypoglycaemic Antiarthritic Anti-inflammatory, anti-allergic, hepatoprotective, antioxidant, antistress, hypotensive, diuretic, antimicrobial activity. 6. Patha Vranahara Kushthaghna Vishaghna Deepana, pachana Shulahara Dahaprashamana Anti-inflammatory Anti-oxidant Anti-venom Anti-leukemic Anti-cancer Anti-ulcer 01-09-2023 FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 16

17. Dosage Traditional dose is – 2 pala or as per digestive strength of the patient. If tablets then 2 BD (500mg) In practice, it is administered in a dose of 1-2 tablets, 2-3 times a day, usually after food. 01-09-2023 FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 17

18. Anupana According to disease condition and prakriti of the patient. 01-09-2023 FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 18

19. All liver disorders are due to the vitiation of Pitta and Virechana is the choice of treatment for all the Pittaja rogas . Patola Katurohinyadi Kashayam is a madhyam shodhana formulation stated in Ashtanga Hridayam Shodhanadi ganasangraha adhyaya . It is Tikta (bitter) rasa predominant which is Pittashamaka in nature. This predominance also attributes to the Vishanasaka (Anti-toxic) property as stated by classics. 01-09-2023 FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 19 Application in Clinical Practice

20. Similarly Laghu guna (light) allows easy absorption and assimilation. The bhedana property of drug is especially correlated with choleretics. The drug which has cholesterics property will stimulate the secretion of bile and the excessive bile cause Virechana . In short the drug has choleretic, hepato-protective, hepato-curative and antioxidant property. Similarly, it can be explained for kushtha chikitsa as well. 01-09-2023 FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 20

21. MANUFACTURING COMPANIES FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 21 01-09-2023 Kottakal Vaidya ratnam Nagarjuna

22. MANUFACTURING COMPANIES 01-09-2023 FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 22 Sitaram ayurveda Arya Vaidya Shala

23. Cost analysis 01-09-2023 FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 23 Company Cost (Rs.) Packing Cost per ml (Rs.) Kottakal 190.00 200 ml 0.95 Vaidyaratnam 185.00 200 ml 0.925 Nagarjuna 220.00 200 ml 1.1 Sitaram ayurveda 294.00 50 T ab 5.88 Arya vaidyashala 240.00 100 Tab 2.4

24. RESEARCH ARTICLE FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 24 01-09-2023

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26. CONCLUSION 01-09-2023 FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 26 In the present case, the treatment protocol was adopted as per Ayurvedic Samprapti and the treatment response was observed much earlier as compared to previous allopathic treatment. No recurrence was reported after the end of active treatment. The importance of a wholesome diet as a health promoter is also revalidated. The external and internal medications of Ayurveda help to correct the complex patho -physiology of psoriasis like chronic diseases. Altogether, multimodal Ayurveda treatment led to speedy and substantial recovery from chronic cases of psoriasis

27. FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 27 01-09-2023

28. CONCLUSION FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 28 01-09-2023 From the above study, an inference can thus be drawn that Patola Katurohinyadi Kashayam is a very potent polyherbal formulation that effectively reduces the symptoms of Panduta , Agnimandya , Aruchi , Hrillas , Trishna, Daha and Bhrama observed in patients suffering from ALD . It is also effective in restoration of normal liver functions as it reduces elevated SGPT and SGOT. Thus it can be advised as a drug of choice in clinical practice

29. DISCUSSION Authentic drug should be used in the preparation to get the required therapeutic property. Patola katurohinyadi kashayam having maximum action on Skin and Liver. In Patolkaturohinyadi kashaya , all drugs are tikta and katu rasa pradhan dravya . Therefore Patolkaturohinyadi kashaya have kapha-pittahara and tridoshahara property. Almost all the ingredients of this Kashaya like Patola , Kutki , Raktachandan , Murva , Guduchi and Patha are Raktaprasadaka , Pittaghna , Kamalanashaka , Pandunashaka and Vishaghna . FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 29 01-09-2023

30. OWN RESEARCH VIEWS Clinical studies can be carried with regard to the other indications given such as vamana , arochaka etc. Studies can be carried out in various types of kushtha . Modification into different dosage forms . FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 30 01-09-2023

31. SUMMARY Introduction Objectives Reference Ingredients Indications Contraindications Pharmaceutical aspects Critical analysis of the ingredients FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 31 Application in Clinical Practice Manufacturing companies Researches Discussion Case study Own research views Summary Conclusion 01-09-2023

32. CONCLUSION Patolakaturohinyadi Kashaya is the most commonly practiced ayurvedic herbal formulation in Kushta , Yukruth roga etc. It is one of the very potent Ayurvedic medicine for jaundice, psoriasis, allergic dermatitis, tinea infection, viral infection and liver diseases. FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 32 01-09-2023

33. 01-09-2023 FORMULATION SEMINAR-PATOLAKATUROHINYADI KASHAYA 33 “Practice dermatology for a better future career” THANK YOU FOR THE PATIENCE Skills_of_dermatology drajithgkumar_derma Doctor_ofskin