PHOTODYNAMIC THERAPY IN PERIODONTICS.pptx

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1. PHOTODYNAMIC THERAPY IN PERIODONTICS. By , Puneet Mehta. P.G. student,Saveetha Dental College Chennai. Guided by , Dr N.D Jaykumar Dr O.Padmalatha Dr Sheeja Vergese Dr Shankari Dr Karthikeyan Dr Jai ganesh

2. AN INSIGHT INTO THE PAST The use of photodynamic therapy for inactivating microorganisms was first demonstrated more than 100 years ago. Oscar Raab first reported the lethal effect of acridine hydrochloride and visible light on  Paramecia caudatum . OSCAR RAAB

3. LIGHT SOURCES A laser or visible light source is used to activate the photosensitizer . Diode laser system & light-emitting diodes are used. Photosensitizers can also be activated by low power visible light at a specific wavelength.  However, in practice, the range of light used in photodynamic therapy is generally >600 nm. This is because endogenous molecules, such as hemoglobin, absorb light strongly at wavelengths of <600 nm and therefore capture most of the incoming photons. This prevents damage to the host components and destroying only the microorganisms.

4. THE PHOTOSENSITIZER Dyes: 1-Tricyclic dyes ( methylene blue, toludine blue O & acridine orange). 2-Phthalocyanines (aluminum disulphonated phthalocyanine and cationic Zn(II) phthalocyanine ) Chlorines: chlorine e6, stannous (IV) chlorine e6, chlorine e6-2.5. N-methyl-d- glucamine (BLC1010), polylysine & polyethyleneimine conjugates of chlorine e6. Porphyrines : haematoporphyrin HCl , photofrin and 5- minolevulinic acid (ALA), benzoporphyrin derivative (BPD) Xanthenes: Erythrocine Monoterpene : azulene

5. HOW DOES IT WORK ???

6. CONCLUSION This new strategy of using photodynamic therapy (PDT) is less traumatic & quicker in the treatment of inflammatory periodontal diseases. PDT in vitro studies have shown greater (> 95%) reduction in micro-organisms. PDT offers numerous advantages, particularly in avoiding emergence of antibiotic resistance species. Well-designed clinical trials are needed for proper evaluation of this therapy. Multi discipline clinical trials should be designed to establish the clinical evidence based effectiveness of PDT.