Premalignant(precancerous)_Lesions_Pathology.pptx

Defination
Premaliganat conditions
Histopathology

1. Premalignant Lesions of Various Organs Department of Pathology

2. Introduction Definition: Premalignant (precancerous) lesions → morphologic alterations with increased risk of malignancy Importance: Early detection & intervention

3. Oral Cavity Leukoplakia – white patch, cannot be scraped off Erythroplakia – red velvety lesion, higher malignant potential Oral submucous fibrosis – due to areca nut chewing

4. Esophagus Barrett’s esophagus – intestinal metaplasia of squamous epithelium → risk of adenocarcinoma

5. Stomach Chronic atrophic gastritis with intestinal metaplasia chronic atrophic gastritis Loss of rugal folds gross chronic atrophic gastritis prominent submucosal vessels gross

6. Intestine / Colon Adenomatous polyps Tubular adenomatous polyp villous adenomatous polyp Hyperplastic polyp Tubulovillous adenomatous

7. Liver Cirrhosis – especially viral & alcoholic cirrhosis Alcoholic Cirrhosis Cirrhosis in Viral Hepatitis

8. Gall Bladder Porcelain gall bladder

9. Gall stones with chronic inflammation

10. Cervix Cervical intraepithelial neoplasia (CIN I-III)

11. a. CIN I b. CIN II c. CIN III

12. Endometrium Endometrial hyperplasia with atypia

13. Breast Atypical ductal hyperplasia (ADH)

14. . Atypical lobular hyperplasia (ALH)

15. Skin Actinic keratosis (sun-exposed areas)

16. Bowen’s disease

17. Prostate Prostatic intraepithelial neoplasia (PIN)

18. Urinary Bladder Urothelial dysplasia / CIS in setting of chronic cystitis, schistosomiasis

19. Summary / Conclusion Premalignant lesions = warning stage Early recognition → prevention of invasive cancer Regular screening & biopsy essential