Psychopharmacology

1. PsychopharmacologyPsychopharmacology

2. PSYCHOPHARMACOLOGYPSYCHOPHARMACOLOGY
AntipsychoticsAntipsychotics
AntiparkinsonismsAntiparkinsonisms
AntidepressantsAntidepressants
Mood stabilizersMood stabilizers
Sedative HypnoticsSedative Hypnotics
Medications used to treat ADHDMedications used to treat ADHD

3. Principles of Principles of
psychopharmacotherapypsychopharmacotherapy
The diagnostic assessment is fundamental to our The diagnostic assessment is fundamental to our
modelmodel
Pharmacotherapy is insufficient for complete Pharmacotherapy is insufficient for complete
recovery.recovery.
The phase of an illness is of critical importance in The phase of an illness is of critical importance in
terms of the initial intervention and the duration of terms of the initial intervention and the duration of
treatmenttreatment
The risks to benefit ratio must always be The risks to benefit ratio must always be
considered when developing a treatment strategyconsidered when developing a treatment strategy

4. Principles of Principles of
psychopharmacotherapypsychopharmacotherapy
Prior personal history of good and bad Prior personal history of good and bad
response to a specific agent usually dictates response to a specific agent usually dictates
the first line of choice for a subsequent the first line of choice for a subsequent
episode.episode.
It is important to target specific symptoms It is important to target specific symptoms
that serves as a marker for the underlying that serves as a marker for the underlying
psychopathology.psychopathology.
Observe the development of adverse side Observe the development of adverse side
effects.effects.

5. Indications of antipsychoticsIndications of antipsychotics
Brief psychotic disordersBrief psychotic disorders
SchizophreniformSchizophreniform
SchizophreniaSchizophrenia
Schizoaffective DisordersSchizoaffective Disorders
Delusional disordersDelusional disorders
Psychotic mood disordersPsychotic mood disorders
Organic psychosesOrganic psychoses

6. AntipsychoticsAntipsychotics
PhenothiazinesPhenothiazines
AliphaticAliphatic
 Chlorpromazine ( Thorazine 25, 50,100mg)Chlorpromazine ( Thorazine 25, 50,100mg)
PiperidinesPiperidines
 Thioridazine ( Melleril 50, 100mg ) Thioridazine ( Melleril 50, 100mg )
 Mesoridazine ( Serentil 10mg.)Mesoridazine ( Serentil 10mg.)
PiperazinesPiperazines
FluphenazineFluphenazine
Perphenazine ( Trilafon 4, & 8 mg.)Perphenazine ( Trilafon 4, & 8 mg.)
Trifluoperazine ( Stelazine 5 mg.)Trifluoperazine ( Stelazine 5 mg.)

7. AntipsychoticsAntipsychotics
THIOXANTHENESTHIOXANTHENES
Thiothexenes – NavaneThiothexenes – Navane
Zuclophentixol HCl – Clopixol 10, 25mg tabZuclophentixol HCl – Clopixol 10, 25mg tab
Zuclophentixol decanoate – Clopixol depotZuclophentixol decanoate – Clopixol depot
Zuclophentixol acetate – Clopixol Acuphase Zuclophentixol acetate – Clopixol Acuphase

8. AntipsychoticsAntipsychotics
ButyrophenonesButyrophenones
Haloperidol ( Haldol, 1, 2, 5, 10 mg/tab) Haloperidol ( Haldol, 1, 2, 5, 10 mg/tab)
( Serenace 5, 10, 20mg/tab )( Serenace 5, 10, 20mg/tab )
( Serenace 5mg/ampule )( Serenace 5mg/ampule )

9. AntipsychoticsAntipsychotics
BenzamidesBenzamides
Sulpiride – DogmatilSulpiride – Dogmatil
Amisulpiride - SolianAmisulpiride - Solian

10. AntipsychoticsAntipsychotics
Serotonin-Dopamine AntagonistsSerotonin-Dopamine Antagonists
DibenzodiazepinesDibenzodiazepines
–Clozapine - LeponexClozapine - Leponex
ThiobenzodiazepinesThiobenzodiazepines
–Olanzapine - ZyprexaOlanzapine - Zyprexa
BenzothiazepinesBenzothiazepines
–Quetiapine - seroquelQuetiapine - seroquel
BenzisoxasolesBenzisoxasoles
–Risperidone - RisperdalRisperidone - Risperdal
Benzisothiasole piperazineBenzisothiasole piperazine
Ziprasidone - Zeldox (Geodon)Ziprasidone - Zeldox (Geodon)

11. UnclassifiedUnclassified
AripiprazoleAripiprazole
– Abilify – 5,10, 15mg/tabAbilify – 5,10, 15mg/tab

12. AntiparkinsonismAntiparkinsonism
Biperidin HCl – Akineton 2mg.Biperidin HCl – Akineton 2mg.
Diphenhydramine – Benadryl 50mgDiphenhydramine – Benadryl 50mg
Amantadine – Symmetrel 100mgAmantadine – Symmetrel 100mg
Benztropine mesylate – Cogentin 2mgBenztropine mesylate – Cogentin 2mg
Trihexylphenidyl HCl – Artane 2mgTrihexylphenidyl HCl – Artane 2mg

13. AntidepressantsAntidepressants
HeterocyclicsHeterocyclics
MAOI’sMAOI’s
RIMARIMA
Dopamine AgonistsDopamine Agonists
SSRISSRI
SNRISNRI

14. AntidepressantsAntidepressants
HeterocyclicsHeterocyclics
TricyclicsTricyclics
Imipramine - TofranilImipramine - Tofranil
Clomipramine - AnafranilClomipramine - Anafranil
TetracyclicsTetracyclics
Maprotiline - LudiomilMaprotiline - Ludiomil
Dothiepine – ProthiadenDothiepine – Prothiaden
Mirtazapine - RemeronMirtazapine - Remeron

15. AntidepressantsAntidepressants
Monoamine Oxidase Inhibitors (MAOIMonoamine Oxidase Inhibitors (MAOI))
Increases biogenic amines by inhibiting their Increases biogenic amines by inhibiting their
degradationdegradation
Should not be taken with foods w/ tyramineShould not be taken with foods w/ tyramine
ExamplesExamples
Tranylcypromine ( Parnate )Tranylcypromine ( Parnate )
Phenelzine ( Nardil )Phenelzine ( Nardil )
Iproniazid ( Marsilid )Iproniazid ( Marsilid )

16. AntidepressantsAntidepressants
Reuptake Inhibitor of Monoamine Oxidase Inhibitor Reuptake Inhibitor of Monoamine Oxidase Inhibitor
type A (RIMA)type A (RIMA)
Moclobemide – Aurorix 150 mgMoclobemide – Aurorix 150 mg
BrofaromineBrofaromine

17. AntidepressantsAntidepressants
Dopamine AgonistsDopamine Agonists
Amineptine HCl – Survector 100mg/tabAmineptine HCl – Survector 100mg/tab

18. AntidepressantsAntidepressants
Selective Serotonin Reuptake Inhibitors (SSRI)Selective Serotonin Reuptake Inhibitors (SSRI)
Paroxetine – Paxil, Seroxat 20/tabParoxetine – Paxil, Seroxat 20/tab
Fluovoxamine – Luvox, Faverin 50mg/tabFluovoxamine – Luvox, Faverin 50mg/tab
Fluoxetine – Prozac 20mg/pulvulesFluoxetine – Prozac 20mg/pulvules
Sertraline – Zoloft 50mg/tabSertraline – Zoloft 50mg/tab

19. AntidepressantsAntidepressants
Serotonin-Norepinephrine Reuptake InhibitorsSerotonin-Norepinephrine Reuptake Inhibitors
Venlafaxine – Effexor 50mg./tabVenlafaxine – Effexor 50mg./tab

20. Medications used for ADHDMedications used for ADHD
StimulantsStimulants
–Methylphenidate –(Ritalin, Metadate, Concerta, Methylphenidate –(Ritalin, Metadate, Concerta,
Daytrana)Daytrana)
–Amphetamine – (Adderall)Amphetamine – (Adderall)
–Dextroamphetamine – (dexedrine, Dextrostat)Dextroamphetamine – (dexedrine, Dextrostat)
–Lisdexamfetamine mesylate ( vyvanse)Lisdexamfetamine mesylate ( vyvanse)
–Non stimulantNon stimulant
Atomoxetine ( Strattera )Atomoxetine ( Strattera )

21. Mood StabilizersMood Stabilizers
Lithium carbonate – Quilonium R 450mg/tabLithium carbonate – Quilonium R 450mg/tab
Carbamazepine – Tegretol 200mg/tabCarbamazepine – Tegretol 200mg/tab
Oxcarbazepine – Trileptal 300 & 600mgOxcarbazepine – Trileptal 300 & 600mg
Depakene – Valproic AcidDepakene – Valproic Acid
Divalproate sodium – Epival 250mg/tabDivalproate sodium – Epival 250mg/tab

22. Sedative - HypnoticsSedative - Hypnotics
BenzodiazepinesBenzodiazepines
ImidazopyridinesImidazopyridines
Cyclopyrrolone derivativesCyclopyrrolone derivatives

23. BenzodiazepinesBenzodiazepines
Estazolam
Lorazepam
ClobazamClorazepate
dipotassium
alprazolamClonazepamFlurazepam
TriazolamMidazolamDiazepam
Short-actingIntermediateLong Acting

24. ImidazopyridinesImidazopyridines
Zolpidem – Stilnox 10mg/tab Ambien in USZolpidem – Stilnox 10mg/tab Ambien in US

25. Cyclopyrrolone derivativeCyclopyrrolone derivative
Zopiclone – Imovane 7.5mg/tabZopiclone – Imovane 7.5mg/tab