Pterocarpus marsupiam in medicinal chemistry

Pterocarpus Marsupiam drug are mention it different type extraction, TLC, Chemical constituent

1. Presented By Puja R. Basule Department of Pharmaceutical Chemistry M-pharm I - year

2. Pterocarpus marsupiam Synonyms: Indian kino tree or Malabar kino, Bijsal, vegisa Bijasar, Hindi: vijayasar, beeja patta, bila Marathi: asaaha, asan, asana, bibla Tamil: acamai, acanapann Telugu: aine, asana, beejasaramu Kannada: baengamara, bange, bendagamara Urdu: bijasar, dam al akhwain Biological source: It consist of the wood and bark of Pterocarpus marsupiam belonging to Family- Fabaceae (Leguminosae)

3. Geographical indication : It is indigenous to Nepal , Srilanka and India (inregions of the Western Ghats in the Karnataka-Kerala region and forest of central India) Dose : 100 and 200 mg/kg

4. EXTRACTION OF DRUG Extraction of main constituent is done by various methods Infusion : Heartwood are filled with water in beaker and allowed to stand overnight to give beeja wood water Decoction : Dried heartwood boiled with water and filtered Maceration : Dried heartwood extracted with ethanol for 1 week Percolation : Coarse powder of heartwood is extracted with 95% alcohol in strenght of 1:6 Hot water extraction : Powdered heartwood extracted with hot water

5. TLC Pterocarpus Marsupium Pterocarpus marsupium Mobile phase Decetion Rf value Alkaloid Toluene: EA: Dietheylamine (7:2:1) Dragendroff 0.40 Steriods Toluene: EA (9:3:0.7 UV 254nm 0.48 Tannins n-butanol:acetic acid:water (14:1:5) Alc Fecl3 0.88,0.67,0.58

6. Chemical Constituents: 2-(3,4,-dihydroxyphenyl ) chromane- 3,5,7 triol

7. Uses Use in diarrhoea. Bleeding and gout problem Skin problem Intestinal parasites Dental problem Anti microbial properties Hyperlipidemia Arthritis

8. Mechanism of action Regeneration Beta-cell has been proposed in diabetics rats treated with epicatechin It was found to increases cAMP content of islets, increaes insulin release Conversion of proinsulin to insulin Reduces blood glucose level in type 2 DM The aqueous extract decreases the elevated TNF-alpha ( effect on glucose metabolism) level in Type-2 DM due to chronic systemic inflammation

9. Some important constituent Epicatechin Structure:  (2R,3R)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol  It is isolated from ethanolic extract

10. Analogs of Epicatechin: Reduces plasma level of glucose ( increaes activity 45-60% more activity than epicatechin)

11. Liquiritigenin Structure:  (S)-7-Hydroxy-2-(4-hydroxyphenyl)chroman-4-one ; 4',7-Dihydroxyflavanone

12. Structure activity relationship: The presence 4’- OH group in the B-Ring and double bond between C 2 and C 3 is important factors for binding and enzyme recognition

13. Isoliquiritigenin Structure: ( E )-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

14. Synthesis: Isomerization

15. Thank You