Rebound Acidity & Lactic Acidosis

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1. Presentation on REBOUND ACIDITY AND LACTIC ACIDOSIS NAME AND ID : ADITI BHOWMICK BPH 05106855 AMRIN JAHAN BPH 05106857 LAMIA ABEDIN BPH O5106864 ATIQUA HAQUE BPH 05106869 PUROBEE BISWAS BPH 05106845

2. What is acid rebound ? ACID REBOUND is a condition when antacid causes our stomach to produce more acid , which worses our GI ( Gastrointestinal ) problems .

3. WHAT IS ANTACID ? ANTACIDS are alkaline base use to neutralize the excess gastric hydrochloric acid associated with gastritis and peptic ulcers . Its pH range of between 3-4 maintain during antacid therapy . Approximate 98% of all stomach acid is neutralize.

4. HOW ANTACID WORK ? ANTACIDS either ditectly neutralize acidity by increasing the pH or reversibly decreases or block the secretion of acid by gastric cells to reduce acidity in the stomach when gastric hydrochloric acid reaches the nerve in the gastrointestinal mucosa , they signal pain to the CNS . This happen when these nerves are exposed .

5. Side effects of antacid

6. WHEN WE TAKE ANTACID ? We take antacid During heart burn Feeling uncomfortable for over eating Growing hungry feeling between meals

7. Mechanism of acid rebound When we take antacid it neutralize the excess gastric hydrochloric acid and it inactivates pepsin . Normally the stomach pH is 1-2.The optimal pH for the proteolytic enzyme,pepsin.Most antacids commonly raise the gastric pH to 4-5 , which greatly reduce pepsin’s proteolytic action and the gastric pH raised too much and acid rebound may occur. To maintain pH ,stomach secrets more HCl which consume the antacide . So for this gastric content, including antacide in the stomach will empty the intestine. As a result, excess acid is secreted into stomach. It occurs in the stomach wall cell .

8. Symptoms of acid rebound Burning pain in the chest or upper abdomen Irritation in the throat Acid taste in the mouth Bad breath Causes nausea Difficult in swallaing.

9. Problem occurs for acid rebound Excess of acid secretion into the stomach leading to a possible hyperacidic condition which further aggravate the ulcer . If antacid is sufficiently water soluble it readily absorb ions and give its alkaline effect , which is a problem for pepsin . Poor blood supply . It causes esophagatis.

10. Treatment of acid rebound Withdrawal from acid-blocking proton pump inhibitor (PPI) therapy . By decreasing the acidity of gastric juice by activating pepsin . By reducing the volume of gastric juice . By surgerical procedure we can treat acid rebound .

11. Lactic acidosis LACTIC ACIDOSIS is a physiological condition chracterized by decreasing pH in the body tissue and blood . It build up of lactate, espically L-lactate and distinct form of metabolic acidosis .

12. Signs , symptoms and causes of lactic acidosis Signs and symptoms : Deep and rapid breath Vomiting Anxiety Abdominal pain Hypertention Causes : Genetic condition Lactose 1,6-diphosphatase deficiency Due to K cyanide Due to hemorrhage Hypoxia

13. Treatment of lactic acidosis Direct removal of lactate from the body is difficult, and there is limited evidence for benefit . By using sodium bicarbonate solution to improve pH . By using medication It may be treated with ketogenic diet and possibly with dichloroacetate

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