Solubility Introduction, Types of Solutions, Solubility Expressions, Solute-Solvent Interaction

Solubility Introduction, Types of Solutions, Solubility Expressions, Solute-Solvent Interaction, Need of understanding solubility

1. SOLUBILITY -1
Presented By:
Mr. S.M. Ambore
Asst. Professor,
DK Patil Institute of Pharmacy, Loha. Nanded

2. LEARNINGOUTCOMES….
Define Solubility
Understand
Different Types of Solutions
Understand
Solubility Expressions
Understand
Solute-Solvent Interaction
2

3. SOLUBILITY
3
Quantitatively
Solubilitycanbedefinedasconcentrationofsolutein
saturatedsolutionatacertaintemperature.
Qualitatively
Solubilitycanbedefinedasspontaneousinteractionof
twoormorecomponentstoformhomogenousmolecular
dispersion.

4. NEEDOFUNDERSTANDING SOLUBILITY
4
1.Selectthebestsolventfordrugormixtureofdrugs
2.Overcomeproblemsduringpreparationofliquid
dosageforms
3.Toknowstructure&intermolecularforcesofdrugs
4.Toenhancethesolubilityofpoorlywatersoluble
drugs

5. 5
SOLUTIONS

6. TYPESOFSOLUTIONS
6

7. REFLECTIONSPOT
Can you guess what will be the types of solutions on the
basis of concentration?
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8. 8
TYPESOFSOLUTIONS

9. 9
SOLUBILITY EXPRESSIONS
AsperUSP,Solubilityofdrugisnumberofmlofsolvent
requiredtodissolve1gmofsolute,whichcanbeclassified
as,
Sr. No.Term Parts of solvent required to 1part of
solute
1 Very soluble Less than 1 part
2 Freely soluble 1-10 parts
3 Soluble 10-30 parts
4 Sparingly soluble 30-100 parts
5 Slightly soluble 100-1000 parts
6 Very Slightlysoluble1000-10000 parts
7 PracticallyinsolubleMorethan 10000 parts
1gm Boric acid requires--18ml water / 4ml glycerin

10. 10
SOLUBILITY EXPRESSIONS
•gm of solute in 100ml solution% w/v
•ml of solute in 100ml solution% v/v
•gm of solute in 100gm solution% w/w
•Moles(gmmol.wt)ofsolutein1000ml
solution
Molarity
•Moles(gmmol.wt)ofsolutein1000gm
solution
Molality
•gmequivalentwtofsolutein1000ml
solution
Normality

11. 11
SOLUTE-SOLVENTINTERACTION

12. 12