Tolerence and autoimmun diseases for laboratorystudents.pptx

tolerence and autoimmune

1. - Which of the following is a non-organ-specific ( systemic ) autoimmune disease : 1   A_ Myasthenia gravis B_ Systemic lupus erythematosus (SLE ) C_ Hashimoto's thyroiditis D_ . Pernicious anemia . E_ Insulin-dependent diabetes mellitus Corect answer is (b ) ✓ 2)- Rheumatoid factors ar e? A- DNA:anti-DNA immune complexes . B_ Autoantibodies to IgM . C_ Autoantibodies to complement components . D_ Autoantibodies to IgG F_ . all of above Correct answer is (D) ✓

2. 3)- difference between organ-specific and nonorgan -specific autoimmune disorders is that?   A -Only in organ-specific autoimmune disorders is there a greater incidence in women. . B - Associations with HLA are only seen in nonorgan-specific autoimmunity C -Circulating autoantibodies react with normal body components only in organspecific autoimmune disorders. D - It is only in organ-specific autoimmune disorders that autoantibody tests are of diagnostic value. E - Only in nonorgan-specific autoimmune diseases are anti-nuclear antibodies a frequent feature Corect answer is (c)✓    

3. 4)_The following is possible mechanis for the recognition of self- componets bthe immune system is autoimmune diseases? a- alterations of self antigene . b-leak of sequestered self antigene . c-loss of suppressor cell . d-all of above. Corect answer is (d)✓  

4.   5)_The pathology in autoimmune disease due to antibody may be result of.....?   a_ formation of immune complexes. b_antibodies blocking cell receptor . c_antibodies induced opsonization. d_antibodies induced coplement . e_ all of above . corect answer is (e)✓   In rheumatoid arthritis the non-lymphoid synovial tissue shows aberrant expression of MHC class II( ) True ✓  

5. Some autoimmune diseases are triggered by microbial antigen ( ✓ ) Glomerular nephritis and endocarditis are complications of streptococcus infection( ✓) SLE disease affects men10times more than women (× ) increasing body fever is characteristic sign In most autoimmune diseases (✓ ) What is the mechanism behind the tissue damage in autoimmune disorders suc h as ? SLE and rheumatoid arthritis Answer: Immune complexes are formed and deposited in the tissues, joints, kidneys, and skin. These immune complexes fix complement and result in tissue damage.   ? What is the cause of type 1 diabetes Answer: Type 1 diabetes results from the autoimmune destruction of insulin producing beta cells in the pancreas what is the factors for tolerance?