Unit11Immunology_Introdunctionpptx__2021_11_23_11_32_00.pptx

Immunology

1. Basics of Immunology (02MB0352) B. Sc. Microbiology, Semester- VI

2. Dear students

3. Live in present ! At present COVID-19 pandemic !!!

4. Countries where COVID-19 has spread (as on 14/11/2021) Number of Countries and Territories: 222 + Number of cases reported: 253,796,914 Active cases: 19,183,940 Recovered: 229,499,706 Number of deaths : 5,113,268 No uniform transmission of disease and death rate; I t depends upon-nature and type of individual/ population

5. With in our friend circle Some are susceptible to some kind of infectious disease Some are resistance to some kind of infectious disease

6. Fighting against disease Fighting with external guards: Masks/social distancing/ sanitizers/ antibiotics/ drugs required and forever Fighting with internal energies/ potentials: Nothing external is required and never Immunity

7. Pathogens

8. Basics of Immunology (Subject Code: 02MB0352)

9. Immunology The term was coined by Russian biologist Ilya Ilyich Mechnikov Received the Nobel Prize in 1908 First time observed the phenomenon of phagocytosis , in which the body defends itself against a foreign body Father of Immunology: Edward Jenner , an English physician and scientist Jenner was the pioneer of the smallpox vaccine Opened the pathway of the discovery of the immune system Immunology is a branch of Biology that covers the study of Immune system of the organism Edward Jenner Ilya Ilyich Mechnikov

10. Immune system ? The immune system is a complex network of organs/ tissues/cells and proteins/ biomolecules that defends the body against infection. The immune system protects our body against invaders/pathogens, such as viruses, bacteria, fungi, protozoa, parasites…. and foreign bodies also CORONA

11. Immunity……Immune system…….Immunology…….. Immunity: Comes from Latin word: Immunis = “ exempt” (In english : Protection from disease) Ability of host to protect itself against pathogen/foreign molecules Immunity Ability of protection from infectious disease Immune system Cellular and molecular components responsible for immunity Immunology Detailed study of Immunosystem functions and mechanism

12. Immune system The immune system is a complex network of cells and their biomolecules associated with defense mechanism of an organism. The immune system protects our body against invaders/pathogens, such as viruses, bacteria, fungi, protozoa, parasites…. and foreign bodies also Protect the host from a universe of pathogenic microbes Eliminate toxic or allergenic substances from the body

13. Objective of the course To provide a fundamental insight of the inner workings of Immune System and its implications on human health. Outcomes of the course: I. Appreciate various components of Immune System II. Differentiate between the development and role of various cells and organs of Immune System III. Rationalize the disease conditions in created during Immune System malfunction Subject: Basics of Immunology Class: B. Sc. Microbiology (Sem. VI) After completion of this course, student will achieve

14. Syllabus UNIT I: Overview of Immune System UNIT II : Antigen and Antibody: Types, Roles, Interactions and Applications UNIT III : Development, Activation and Communication in Adaptive Immunity UNIT IV : Immunology in Health and Diseases

15. Unit I: Overview of Immune System History of immunology Functional role of Immune System Types of Immunity: Innate and adaptive immunity Physical barriers to infection Cells and organs of the innate and adaptive immune system Haematopoiesis .

16. Unit II: Antigen and Antibody: Types, Roles, Interactions and Applications Antigen: Characteristics of antigens Factors that influence immunogenicity; Cross reactivity; Epitopes; Haptens, Adjuvants. Immunoglobulins : Structure, Classification & Functions Organization & Synthesis of Light chain genes & Heavy chain genes, Class & Isotype Switching Monoclonal Antibodies: Production by Hybridoma Technology & Applications Antigen and Antibody Interactions- Agglutination, Precipitation ELISA , RIA, Immunoflorescence & Western Blotting

17. Unit III: Development, Activation and Communication in Adaptive Immunity MHC molecules and organisation of their genes Structure and function of MHC gene products Antigen Processing and Presentations T- Cell Receptor and B cell Receptor T- Cell Maturation, Activation, Differentiation B- Cell Maturation, Activation, Differentiation Cytokines : Properties of Cytokines; Cytokine receptors; Function of Cytokines Complement System: Function; Component; Activation and Regulation Cell Mediated Effector Responses

18. Unit IV: Immunology in Health and Diseases Immune response to Infectious Diseases: Viral (Influenza); Bacterial (Tuberculosis); Protozoan ( Malaria) Immunodeficiency Diseases: Primary (SCID) & Secondary (AIDS ) Autoimmune Diseases: Organ Specific (Graves disease; Insulin dependent diabeties mallitus ) Systemic Autoimmune Diseases (Rheumatoid Arthritis; Multiple sclerosis) Transplantation Immunology: Graft rejection; Evidence & Mechanism of Graft rejection Prevention of Graft rejection Immunosuppressive Drugs Hypersensitive Reactions Inflammatory response Vaccines and there types

19. Reference Books B. M. Hannigan, C. B. T. Moore and D. G. Quinn (2010) Immunology 2nd Edn ., Viva Books. K. D. Elgert (2009) Immunology, 2nd Edn ., Wiley Blackwell. K. M. Murphy, P. Travers, M. Walport (2011) Janeway’s Immunobiology , 8th Edition, Garland Science. W. E. Paul (2008) Fundamental Immunology, 6th Edition, Lippincott Williams & Wilkins. K. Abbas, A. H. Lichtman & S. Pillai (2007) Cellular and Molecular Immunology, 6th Edition, Saunders. Kindt , T. J., Osborne, B. A. & Goldsby , R. A. (2006) Kuby Immunology, 6th edition, W. H. Freeman. P. J. Delves, S. J. Martin, D. R. Burton and I. M. Roitt (2006) Roitt’s Essential Immunology 11th Edn ., Blackwell Publ.. D. Male, J. Brostoff , D. B. Roth & I. Roitt (2006) Immunology, 7th Edn ., Mosby-Elsevier. T. W. Mak and M. E. Saunders (2006) The Immune Response – Basic and Clinical Principles, Academic Press. R. Coico , G. Sunshine and E. Benjamini (2003) Immunology - A Short Course, 5th edition, John Wiley & Sons. M. Wilson (2005) Microbial inhabitants of humans, Cambridge Univ. Press.   F. H. Khan (2009) The Elements of Immunology, Pearson education press  

20. Books available at Marwadi university library Author: Judy Owen I Jenni Punt I Sharon Stranford Publisher: WH Freeman ISBN-13 : 978-1429219198 Edition: 7 th ed. I have eBook of Kuby Immunology, I will share with you.

21. Any Questions? Thank You… Boost your immunity with these foods